What compounds affect the Mitochondrial protein import pathway?

44 compounds in the BiohacksAI corpus have documented interactions with genes in the Mitochondrial protein import pathway (Reactome ID: R-HSA-1268020). These compounds target 3 genes within this pathway.

What genes are in the Mitochondrial protein import pathway?

The Mitochondrial protein import pathway involves 3 genes. Key genes include: FXN, GFER, HSPD1.

Mitochondrial protein import

REACTOME PATHWAY

Reactome: R-HSA-12680203 genes44 compounds

The Mitochondrial protein import pathway (Reactome ID: R-HSA-1268020) involves 3 genes and is affected by 44 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

FXN GFER HSPD1

Compounds Affecting Mitochondrial protein import

#	Compound	Targets Hit	Studies
1	Arachidonic Acid	—	245
2	Aurintricarboxylic Acid	—	184
3	Disulfiram	—	297
4	Vanillic Acid	—	300
5	pterostilbene	—	299
6	Resveratrol	—	298
7	Phenelzine	—	2
8	piceatannol	—	300
9	Promazine	—	40
10	Promethazine	—	121
11	caffeic acid	—	300
12	Chlorogenic Acid	—	300
13	Methylene Blue	—	200
14	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
15	Kaempferols	—	300
16	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	1,000
17	Rutin	—	300
18	2-Methoxyestradiol	—	300
19	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	293
20	Bufexamac	—	137
21	calycosin	—	300
22	Catechin	—	300
23	Equilin	—	216
24	Masoprocol	—	300
25	Perphenazine	—	297
26	propionylpromazine hydrochloride	—	2
27	4-Hydroxybenzoate-3-Monooxygenase	—	300
28	alphitonin [Supplementary Concept] from	—	300
29	Thioridazine	—	35
30	triflupromazine hydrochloride	—	12
31	urolithin b	—	49
32	egcg	—	300
33	plumbagin [Supplementary Concept]	—	300
34	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
35	Adapalene	—	296
36	Evans Blue	—	300
37	Hexachlorophene	—	300
38	Lithocholic Acid	—	300
39	rafoxanide	—	172
40	Demeclocycline	—	5
41	Dinitrochlorobenzene	—	300
42	kenpaullone	—	8
43	Vorinostat	—	299
44	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150

About the Mitochondrial protein import Pathway

The Mitochondrial protein import pathway is catalogued in Reactome (ID: R-HSA-1268020) and involves 3 genes. In the BiohacksAI corpus, 44 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include FXN, GFER, HSPD1.