What compounds affect the Ca2+ activated K+ channels pathway?

56 compounds in the BiohacksAI corpus have documented interactions with genes in the Ca2+ activated K+ channels pathway (Reactome ID: R-HSA-1296052). These compounds target 7 genes within this pathway.

What genes are in the Ca2+ activated K+ channels pathway?

The Ca2+ activated K+ channels pathway involves 7 genes. Key genes include: KCNMA1, KCNMB1, KCNMB2, KCNMB4, KCNN1, KCNN3, KCNN4.

Ca2+ activated K+ channels

REACTOME PATHWAY

Reactome: R-HSA-12960527 genes56 compounds

The Ca2+ activated K+ channels pathway (Reactome ID: R-HSA-1296052) involves 7 genes and is affected by 56 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

KCNMA1 KCNMB1 KCNMB2 KCNMB4 KCNN1 KCNN3 KCNN4

Compounds Affecting Ca2+ activated K+ channels

#	Compound	Targets Hit	Studies
1	pterostilbene	—	299
2	Carvedilol	—	296
3	Fluocinolone Acetonide	—	295
4	Latanoprost	—	299
5	Nisoldipine	—	297
6	Promethazine	—	121
7	Thioridazine	—	35
8	nafadotride	—	14
9	3',4'-didemethylnobiletin [Supplementary Concept]	—	300
10	Nortriptyline	—	28
11	Perphenazine	—	297
12	Ritonavir	—	298
13	Budesonide	—	1,000
14	Resveratrol	—	298
15	Ethylestrenol	—	70
16	Ezetimibe	—	296
17	Thyroxine	—	994
18	Amoxapine	—	259
19	Thyroxine	—	300
20	Riluzole	—	298
21	Glyburide	—	298
22	Irbesartan	—	298
23	Simvastatin	—	1,000
24	Oxcarbazepine	—	296
25	Ursodeoxycholic Acid	—	298
26	Lovastatin	—	300
27	Nicardipine	—	94
28	Dequalinium	—	46
29	Tubocurarine	—	300
30	Dequalinium	—	136
31	Oxaprozin	—	181
32	Calcitriol	—	300
33	Chlorpheniramine	—	157
34	Desoximetasone	—	86
35	Disulfiram	—	297
36	Etodolac	—	296
37	Levonorgestrel	—	292
38	Norgestrel	—	300
39	Amdinocillin	—	100
40	Aminolevulinic Acid	—	299
41	Artemether	—	299
42	Cetirizine	—	296
43	Ethinyl Estradiol	—	300
44	Pemoline	—	300
45	Tocainide	—	299
46	Norethindrone Acetate Acetate ester of norethindrone that is used as	—	300
47	Methyltestosterone	—	300
48	Nateglinide	—	295
49	Flutamide	—	298
50	Imatinib Mesylate	—	300

About the Ca2+ activated K+ channels Pathway

The Ca2+ activated K+ channels pathway is catalogued in Reactome (ID: R-HSA-1296052) and involves 7 genes. In the BiohacksAI corpus, 56 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include KCNMA1, KCNMB1, KCNMB2, KCNMB4, KCNN1.