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Amoxapine

The N-demethylated derivative of the antipsychotic agent LOXAPINE that works by blocking the reuptake of norepinephrine, serotonin, or both; it also blocks dopamine receptors. Amoxapine is used for the treatment of depression.

259+ PubMed studies analyzed · 18 RCTs · Evidence Score: 44.3

Research Domains

Amoxapine has been studied across 13 research domains including 🌤️ Mood & Depression, 🧠 Focus & Attention, ✨ Skin & Hair, 🫘 Kidney, 🧠 Neuroprotection. The primary research focus is 🌤️ Mood & Depression with 33% of studies addressing this area.

Similar Compounds by Shared Targets

The following compounds share molecular targets with Amoxapine, based on binding affinity data from BindingDB and ChEMBL. Sorted by shared target overlap.

Promethazine
44 shared targets
Nortriptyline
47 shared targets
Maprotiline
43 shared targets
Cyproheptadine
44 shared targets
Mianserin
40 shared targets
Loxapine
33 shared targets
Quetiapine
35 shared targets
Metergoline
45 shared targets
Amitriptyline
44 shared targets
Domperidone
36 shared targets
Loading evidence profile...

This evidence profile for Amoxapine is generated deterministically from 259 PubMed-indexed studies. All data is corpus-verified with Merkle proofs. BiohacksAI does not provide medical advice. Always consult a healthcare professional before starting any supplement regimen.

Data source: PubMed/MEDLINE (NLM). Corpus version: current. Patent pending (EVE-PAT-2026-001). © 2026 Organiq Sweden AB.