Downregulation of ERBB2:ERBB3 signaling
REACTOME PATHWAYThe Downregulation of ERBB2:ERBB3 signaling pathway (Reactome ID: R-HSA-1358803) involves 4 genes and is affected by 10 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Downregulation of ERBB2:ERBB3 signaling
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Afatinib | — | 297 |
| 2 | Luteolin 5,7,3',4'-tetrahydroxy-flavone, | — | 150 |
| 3 | Adapalene | — | 296 |
| 4 | alpha-Linolenic Acid | — | 300 |
| 5 | Quercetin | — | 300 |
| 6 | celastrol | — | 300 |
| 7 | prunetin | — | 35 |
| 8 | Dasatinib | — | 299 |
| 9 | tyrphostin ag 1478 | — | 4 |
| 10 | hydroxyfasudil [Supplementary Concept] | — | 11 |
About the Downregulation of ERBB2:ERBB3 signaling Pathway
The Downregulation of ERBB2:ERBB3 signaling pathway is catalogued in Reactome (ID: R-HSA-1358803) and involves 4 genes. In the BiohacksAI corpus, 10 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AKT3, ERBB2, ERBB3, USP8.