Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
REACTOME PATHWAYThe Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 pathway (Reactome ID: R-HSA-1362300) involves 2 genes and is affected by 27 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | kenpaullone | — | 8 |
| 2 | alsterpaullone | — | 12 |
| 3 | indirubin | — | 300 |
| 4 | Clofibrate | — | 299 |
| 5 | Fenofibrate | — | 297 |
| 6 | Sertraline | — | 1,000 |
| 7 | Cinnarizine | — | 299 |
| 8 | Clotrimazole | — | 296 |
| 9 | Rotenone | — | 300 |
| 10 | Apigenin 5,7,4'-trihydroxy-flavone, | — | 300 |
| 11 | chrysin | — | 300 |
| 12 | fisetin | — | 78 |
| 13 | Luteolin 5,7,3',4'-tetrahydroxy-flavone, | — | 150 |
| 14 | Quercetin | — | 300 |
| 15 | Sorafenib | — | 300 |
| 16 | sp600125 | — | 117 |
| 17 | Vorinostat | — | 299 |
| 18 | trichostatic acid [Supplementary Concept] related to trichostatin | — | 300 |
| 19 | scriptaid | — | 53 |
| 20 | Valproic Acid | — | 296 |
| 21 | pictilisib | — | 25 |
| 22 | Butyric Acid | — | 300 |
| 23 | Ursolic Acid | — | 300 |
| 24 | Celecoxib | — | 295 |
| 25 | Daunorubicin | — | 298 |
| 26 | Bortezomib | — | 300 |
| 27 | Camptothecin | — | 300 |
About the Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 Pathway
The Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 pathway is catalogued in Reactome (ID: R-HSA-1362300) and involves 2 genes. In the BiohacksAI corpus, 27 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CDK1, HDAC1.