What genes are in the Amplification of signal from the kinetochores pathway?

The Amplification of signal from the kinetochores pathway involves 8 genes. Key genes include: AURKB, BIRC5, PLK1, PPP1CC, PPP2CA, PPP2R5A, TAOK1, XPO1.

Amplification of signal from the kinetochores

Q: What compounds affect the Amplification of signal from the kinetochores pathway?

34 compounds in the BiohacksAI corpus have documented interactions with genes in the Amplification of signal from the kinetochores pathway (Reactome ID: R-HSA-141424). These compounds target 8 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-1414248 genes34 compounds

The Amplification of signal from the kinetochores pathway (Reactome ID: R-HSA-141424) involves 8 genes and is affected by 34 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AURKB BIRC5 PLK1 PPP1CC PPP2CA PPP2R5A TAOK1 XPO1

Compounds Affecting Amplification of signal from the kinetochores

#	Compound	Targets Hit	Studies
1	Okadaic Acid	—	300
2	Sorafenib	—	300
3	sp600125	—	117
4	Quercetin	—	300
5	Crizotinib	—	298
6	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
7	Dasatinib	—	299
8	fisetin	—	78
9	Axitinib	—	298
10	kenpaullone	—	8
11	1-(5,8-dihydro-1,4-dihydroxy-5,8-dioxo-2-naphthyl)-4-methylpent-3-en-1-yl cinnamate [Supplementary Concept]	—	54
12	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
13	Kaempferols	—	300
14	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
15	hydroxyfasudil [Supplementary Concept]	—	11
16	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
17	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
18	scutellarein	—	113
19	tamarixetin	—	26
20	ly294002	—	11
21	Wortmannin	—	300
22	Oleic Acid	—	112
23	Simvastatin	—	1,000
24	cefaclor	—	299
25	Disulfiram	—	297
26	Hexachlorophene	—	300
27	Lithocholic Acid	—	300
28	Nisoldipine	—	297
29	Oxyphenbutazone	—	300
30	Oxytetracycline	—	300
31	plumbagin [Supplementary Concept]	—	300
32	oridonin	—	300
33	Buthionine Sulfoximine	—	300
34	Vitamin K 3	—	300

About the Amplification of signal from the kinetochores Pathway

The Amplification of signal from the kinetochores pathway is catalogued in Reactome (ID: R-HSA-141424) and involves 8 genes. In the BiohacksAI corpus, 34 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AURKB, BIRC5, PLK1, PPP1CC, PPP2CA.