A synthetic amino acid that depletes glutathione by irreversibly inhibiting gamma-glutamylcysteine synthetase. Inhibition of this enzyme is a critical step in glutathione biosynthesis. It has been shown to inhibit the proliferative response in human T-lymphocytes and inhibit macrophage activation. (J Biol Chem 1995;270(33):1945-7)
Buthionine Sulfoximine has been studied across 18 research domains including 🫁 Liver & Detox, 🔬 Oncology, 🔬 Inflammation, 🫘 Kidney, ⚡ Energy & Fatigue. The primary research focus is 🫁 Liver & Detox with 82% of studies addressing this area.
The following compounds share molecular targets with Buthionine Sulfoximine, based on binding affinity data from BindingDB and ChEMBL. Sorted by shared target overlap.
This evidence profile for Buthionine Sulfoximine is generated deterministically from 300 PubMed-indexed studies. All data is corpus-verified with Merkle proofs. BiohacksAI does not provide medical advice. Always consult a healthcare professional before starting any supplement regimen.
Data source: PubMed/MEDLINE (NLM). Corpus version: current. Patent pending (EVE-PAT-2026-001). © 2026 Organiq Sweden AB.