Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
REACTOME PATHWAYThe Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal pathway (Reactome ID: R-HSA-141444) involves 8 genes and is affected by 34 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Okadaic Acid | — | 300 |
| 2 | Sorafenib | — | 300 |
| 3 | sp600125 | — | 117 |
| 4 | Quercetin | — | 300 |
| 5 | Crizotinib | — | 298 |
| 6 | myricetin-3-O-galactopyranoside [Supplementary Concept] | — | 300 |
| 7 | Dasatinib | — | 299 |
| 8 | fisetin | — | 78 |
| 9 | Axitinib | — | 298 |
| 10 | kenpaullone | — | 8 |
| 11 | 1-(5,8-dihydro-1,4-dihydroxy-5,8-dioxo-2-naphthyl)-4-methylpent-3-en-1-yl cinnamate [Supplementary Concept] | — | 54 |
| 12 | Apigenin 5,7,4'-trihydroxy-flavone, | — | 300 |
| 13 | Kaempferols | — | 300 |
| 14 | Luteolin 5,7,3',4'-tetrahydroxy-flavone, | — | 150 |
| 15 | hydroxyfasudil [Supplementary Concept] | — | 11 |
| 16 | isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from | — | 300 |
| 17 | juglone hydroxylase [Supplementary Concept] catalyzes | — | 279 |
| 18 | scutellarein | — | 113 |
| 19 | tamarixetin | — | 26 |
| 20 | ly294002 | — | 11 |
| 21 | Wortmannin | — | 300 |
| 22 | Oleic Acid | — | 112 |
| 23 | Simvastatin | — | 1,000 |
| 24 | cefaclor | — | 299 |
| 25 | Disulfiram | — | 297 |
| 26 | Hexachlorophene | — | 300 |
| 27 | Lithocholic Acid | — | 300 |
| 28 | Nisoldipine | — | 297 |
| 29 | Oxyphenbutazone | — | 300 |
| 30 | Oxytetracycline | — | 300 |
| 31 | plumbagin [Supplementary Concept] | — | 300 |
| 32 | oridonin | — | 300 |
| 33 | Buthionine Sulfoximine | — | 300 |
| 34 | Vitamin K 3 | — | 300 |
About the Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Pathway
The Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal pathway is catalogued in Reactome (ID: R-HSA-141444) and involves 8 genes. In the BiohacksAI corpus, 34 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AURKB, BIRC5, PLK1, PPP1CC, PPP2CA.