Question 1

What compounds affect the Degradation of the extracellular matrix pathway?

Accepted Answer

25 compounds in the BiohacksAI corpus have documented interactions with genes in the Degradation of the extracellular matrix pathway (Reactome ID: R-HSA-1474228). These compounds target 20 genes within this pathway.

Question 2

What genes are in the Degradation of the extracellular matrix pathway?

Accepted Answer

The Degradation of the extracellular matrix pathway involves 20 genes. Key genes include: ADAM10, ADAM17, ADAMTS4, ADAMTS5, CAPN1, CMA1, CTRB1, CTSG, CTSL, ELANE.

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Bisphenol A-Glycidyl Methacrylate	—	197
3	Kaempferols	—	300
4	egcg	—	300
5	piceatannol	—	300
6	Sulfaguanidine	—	255
7	Dihydroergocristine	—	187
8	Gabexate	—	300
9	Resveratrol	—	298
10	Astemizole Antihistamine drug now withdrawn from	—	280
11	Leflunomide	—	297
12	Propafenone	—	14
13	Thioridazine	—	35
14	Progesterone	—	299
15	Hexachlorophene	—	300
16	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
17	Prednisolone	—	1,000
18	Harmaline	—	300
19	sp600125	—	117
20	Methotrexate	—	289
21	Ursolic Acid	—	300
22	Diminazene	—	300
23	silver sulfadiazine	—	299
24	Doxycycline	—	999
25	Triamcinolone	—	300

BiohacksAI

Degradation of the extracellular matrix

Genes in this Pathway

Compounds Affecting Degradation of the extracellular matrix

About the Degradation of the extracellular matrix Pathway