What compounds affect the PKA activation pathway?

18 compounds in the BiohacksAI corpus have documented interactions with genes in the PKA activation pathway (Reactome ID: R-HSA-163615). These compounds target 4 genes within this pathway.

What genes are in the PKA activation pathway?

The PKA activation pathway involves 4 genes. Key genes include: ADCY9, PRKACA, PRKACB, PRKACG.

PKA activation

REACTOME PATHWAY

Reactome: R-HSA-1636154 genes18 compounds

The PKA activation pathway (Reactome ID: R-HSA-163615) involves 4 genes and is affected by 18 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADCY9 PRKACA PRKACB PRKACG

Compounds Affecting PKA activation

#	Compound	Targets Hit	Studies
1	hydroxyfasudil [Supplementary Concept]	—	11
2	Carmustine	—	297
3	Edaravone	—	298
4	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
5	Iodoacetamide	—	300
6	Cisplatin	—	300
7	Cilostazol	—	297
8	Disulfiram	—	297
9	Physostigmine	—	300
10	Ethylmaleimide	—	300
11	Physostigmine	—	299
12	tyrphostin 1	—	1
13	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
14	arctigenin-4-O-(3''-O-acetyl-beta-D-glucoside) [Supplementary Concept] isolated from	—	300
15	Aurintricarboxylic Acid	—	184
16	Diamide	—	300
17	alpelisib	—	227
18	Sphingosine	—	300

About the PKA activation Pathway

The PKA activation pathway is catalogued in Reactome (ID: R-HSA-163615) and involves 4 genes. In the BiohacksAI corpus, 18 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADCY9, PRKACA, PRKACB, PRKACG.