PKA activation in glucagon signalling
REACTOME PATHWAYThe PKA activation in glucagon signalling pathway (Reactome ID: R-HSA-164378) involves 5 genes and is affected by 22 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting PKA activation in glucagon signalling
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | hydroxyfasudil [Supplementary Concept] | — | 11 |
| 2 | Carmustine | — | 297 |
| 3 | Edaravone | — | 298 |
| 4 | Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as | — | 300 |
| 5 | Iodoacetamide | — | 300 |
| 6 | Cisplatin | — | 300 |
| 7 | Cilostazol | — | 297 |
| 8 | Disulfiram | — | 297 |
| 9 | Physostigmine | — | 300 |
| 10 | Ethylmaleimide | — | 300 |
| 11 | Physostigmine | — | 299 |
| 12 | tyrphostin 1 | — | 1 |
| 13 | myricetin-3-O-galactopyranoside [Supplementary Concept] | — | 300 |
| 14 | arctigenin-4-O-(3''-O-acetyl-beta-D-glucoside) [Supplementary Concept] isolated from | — | 300 |
| 15 | Aurintricarboxylic Acid | — | 184 |
| 16 | Diamide | — | 300 |
| 17 | Niclosamide | — | 299 |
| 18 | Tetraethylammonium | — | 119 |
| 19 | Triacetin | — | 300 |
| 20 | urolithin b | — | 49 |
| 21 | alpelisib | — | 227 |
| 22 | Sphingosine | — | 300 |
About the PKA activation in glucagon signalling Pathway
The PKA activation in glucagon signalling pathway is catalogued in Reactome (ID: R-HSA-164378) and involves 5 genes. In the BiohacksAI corpus, 22 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADCY9, GNAS, PRKACA, PRKACB, PRKACG.