Regulation of cholesterol biosynthesis by SREBP (SREBF)

Q: What compounds affect the Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway?

105 compounds in the BiohacksAI corpus have documented interactions with genes in the Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway (Reactome ID: R-HSA-1655829). These compounds target 14 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-165582914 genes105 compounds

The Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway (Reactome ID: R-HSA-1655829) involves 14 genes and is affected by 105 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CARM1 CREBBP CYP51A1 FASN FDPS HMGCR KPNB1 NCOA1 PPARA RAN RXRA SCAP SREBF1 SREBF2

Compounds Affecting Regulation of cholesterol biosynthesis by SREBP (SREBF)

#	Compound	Targets Hit	Studies
1	Aldosterone	—	300
2	Arachidonic Acid	—	245
3	Gemfibrozil	—	297
4	Rosuvastatin Calcium	—	216
5	Oleic Acid	—	112
6	Atorvastatin	—	1,000
7	Reserpine	—	297
8	Calcifediol	—	300
9	Dehydroepiandrosterone Sulfate	—	300
10	methyl 13-(alpha-naphthalene)aminodeisopropyldehydroabietate [Supplementary Concept]	—	161
11	Sulindac	—	297
12	Thyroxine	—	994
13	Progesterone	—	299
14	Vitamin	—	295
15	Calcitriol	—	300
16	Dactinomycin	—	297
17	Domperidone	—	299
18	Ethylene Chlorohydrin Used as	—	73
19	Phenol	—	297
20	Retinaldehyde	—	300
21	Ribitol	—	297
22	Sorbic Acid Mold and yeast inhibitor. Used as	—	300
23	Stavudine	—	298
24	Sulfanilamide	—	300
25	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
26	Thyroxine	—	300
27	Xylitol	—	300
28	Genistein	—	300
29	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	1,000
30	Quercetin	—	300
31	Testosterone	—	299
32	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	293
33	Acetylcysteine	—	298
34	Adenosine	—	298
35	Anthraquinones Compounds based on ANTHRACENES which contain two KETONES in	—	300
36	Chloral Hydrate	—	298
37	Chloralose	—	300
38	Cilostazol	—	297
39	Diflubenzuron	—	300
40	Dihydrotestosterone	—	300
41	dimethyl formamide	—	260
42	Dimethylformamide	—	300
43	Diuron	—	300
44	Ethidium	—	300
45	Ezetimibe	—	296
46	Flutamide	—	298
47	Lutein	—	300
48	Niclosamide	—	299
49	Niflumic Acid	—	300
50	Nitrofurazone	—	300

About the Regulation of cholesterol biosynthesis by SREBP (SREBF) Pathway

The Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway is catalogued in Reactome (ID: R-HSA-1655829) and involves 14 genes. In the BiohacksAI corpus, 105 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CARM1, CREBBP, CYP51A1, FASN, FDPS.