Cdc20:Phospho-APC/C mediated degradation of Cyclin A
REACTOME PATHWAYThe Cdc20:Phospho-APC/C mediated degradation of Cyclin A pathway (Reactome ID: R-HSA-174184) involves 34 genes and is affected by 26 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Cdc20:Phospho-APC/C mediated degradation of Cyclin A
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Bortezomib | — | 300 |
| 2 | Reserpine | — | 297 |
| 3 | kenpaullone | — | 8 |
| 4 | alsterpaullone | — | 12 |
| 5 | Apigenin 5,7,4'-trihydroxy-flavone, | — | 300 |
| 6 | chrysin | — | 300 |
| 7 | Luteolin 5,7,3',4'-tetrahydroxy-flavone, | — | 150 |
| 8 | Quercetin | — | 300 |
| 9 | sp600125 | — | 117 |
| 10 | Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as | — | 300 |
| 11 | indirubin | — | 300 |
| 12 | Clofibrate | — | 299 |
| 13 | Fenofibrate | — | 297 |
| 14 | Sertraline | — | 1,000 |
| 15 | Cinnarizine | — | 299 |
| 16 | Clotrimazole | — | 296 |
| 17 | Rotenone | — | 300 |
| 18 | fisetin | — | 78 |
| 19 | Sorafenib | — | 300 |
| 20 | Disulfiram | — | 297 |
| 21 | 4-Hydroxybenzoate-3-Monooxygenase | — | 300 |
| 22 | egcg | — | 300 |
| 23 | Genistein | — | 300 |
| 24 | myricetin-3-O-galactopyranoside [Supplementary Concept] | — | 300 |
| 25 | Pioglitazone | — | 297 |
| 26 | Harmaline | — | 300 |
About the Cdc20:Phospho-APC/C mediated degradation of Cyclin A Pathway
The Cdc20:Phospho-APC/C mediated degradation of Cyclin A pathway is catalogued in Reactome (ID: R-HSA-174184) and involves 34 genes. In the BiohacksAI corpus, 26 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, CCNA1, CDK1, PSMA1, PSMA2.