Question 1

What compounds affect the APC/C:Cdc20 mediated degradation of mitotic proteins pathway?

Accepted Answer

27 compounds in the BiohacksAI corpus have documented interactions with genes in the APC/C:Cdc20 mediated degradation of mitotic proteins pathway (Reactome ID: R-HSA-176409). These compounds target 36 genes within this pathway.

Question 2

What genes are in the APC/C:Cdc20 mediated degradation of mitotic proteins pathway?

Accepted Answer

The APC/C:Cdc20 mediated degradation of mitotic proteins pathway involves 36 genes. Key genes include: ADRM1, CCNA1, CCNB1, CDK1, NEK2, PSMA1, PSMA2, PSMA3, PSMA4, PSMA5.

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	kenpaullone	—	8
4	alsterpaullone	—	12
5	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
6	chrysin	—	300
7	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
8	Quercetin	—	300
9	sp600125	—	117
10	indirubin	—	300
11	fisetin	—	78
12	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
13	Clofibrate	—	299
14	Fenofibrate	—	297
15	Sertraline	—	1,000
16	Cinnarizine	—	299
17	Clotrimazole	—	296
18	Rotenone	—	300
19	Sorafenib	—	300
20	Disulfiram	—	297
21	4-Hydroxybenzoate-3-Monooxygenase	—	300
22	egcg	—	300
23	Genistein	—	300
24	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
25	Vemurafenib	—	298
26	Pioglitazone	—	297
27	Harmaline	—	300

BiohacksAI

APC/C:Cdc20 mediated degradation of mitotic proteins

Genes in this Pathway

Compounds Affecting APC/C:Cdc20 mediated degradation of mitotic proteins

About the APC/C:Cdc20 mediated degradation of mitotic proteins Pathway