What compounds affect the Phosphorylation of the APC/C pathway?

28 compounds in the BiohacksAI corpus have documented interactions with genes in the Phosphorylation of the APC/C pathway (Reactome ID: R-HSA-176412). These compounds target 3 genes within this pathway.

What genes are in the Phosphorylation of the APC/C pathway?

The Phosphorylation of the APC/C pathway involves 3 genes. Key genes include: CCNB1, CDK1, PLK1.

Phosphorylation of the APC/C

REACTOME PATHWAY

Reactome: R-HSA-1764123 genes28 compounds

The Phosphorylation of the APC/C pathway (Reactome ID: R-HSA-176412) involves 3 genes and is affected by 28 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CCNB1 CDK1 PLK1

Compounds Affecting Phosphorylation of the APC/C

#	Compound	Targets Hit	Studies
1	kenpaullone	—	8
2	alsterpaullone	—	12
3	indirubin	—	300
4	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
5	chrysin	—	300
6	fisetin	—	78
7	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
8	Quercetin	—	300
9	Clofibrate	—	299
10	Fenofibrate	—	297
11	Sertraline	—	1,000
12	Cinnarizine	—	299
13	Clotrimazole	—	296
14	Rotenone	—	300
15	Sorafenib	—	300
16	sp600125	—	117
17	ly294002	—	11
18	Wortmannin	—	300
19	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
20	Oleic Acid	—	112
21	Simvastatin	—	1,000
22	cefaclor	—	299
23	Disulfiram	—	297
24	Hexachlorophene	—	300
25	Lithocholic Acid	—	300
26	Nisoldipine	—	297
27	Oxyphenbutazone	—	300
28	Oxytetracycline	—	300

About the Phosphorylation of the APC/C Pathway

The Phosphorylation of the APC/C pathway is catalogued in Reactome (ID: R-HSA-176412) and involves 3 genes. In the BiohacksAI corpus, 28 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CCNB1, CDK1, PLK1.