What compounds affect the Signaling by EGFR pathway?

29 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by EGFR pathway (Reactome ID: R-HSA-177929). These compounds target 9 genes within this pathway.

What genes are in the Signaling by EGFR pathway?

The Signaling by EGFR pathway involves 9 genes. Key genes include: ADAM10, ADAM17, CDC42, CSK, EGFR, GRB2, PIK3R1, PTPRK, SRC.

Signaling by EGFR

REACTOME PATHWAY

Reactome: R-HSA-1779299 genes29 compounds

The Signaling by EGFR pathway (Reactome ID: R-HSA-177929) involves 9 genes and is affected by 29 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADAM10 ADAM17 CDC42 CSK EGFR GRB2 PIK3R1 PTPRK SRC

Compounds Affecting Signaling by EGFR

#	Compound	Targets Hit	Studies
1	Dasatinib	—	299
2	tyrphostin ag 1478	—	4
3	Sorafenib	—	300
4	Quercetin	—	300
5	Afatinib	—	297
6	Bisphenol A-Glycidyl Methacrylate	—	197
7	Kaempferols	—	300
8	Resveratrol	—	298
9	Adenosine Monophosphate Adenine nucleotide containing	—	300
10	alsterpaullone	—	12
11	Crizotinib	—	298
12	kenpaullone	—	8
13	monorden	—	8
14	Niclosamide	—	299
15	pictilisib	—	25
16	Wortmannin	—	300
17	ly294002	—	11
18	alpelisib	—	227
19	Sirolimus	—	300
20	torin 1	—	10
21	ag490	—	14
22	tyrphostin 1	—	1
23	Progesterone	—	299
24	Hexachlorophene	—	300
25	Prednisolone	—	1,000
26	Axitinib	—	298
27	casin	—	10
28	Dactinomycin	—	297
29	Sodium Fluoride	—	299

About the Signaling by EGFR Pathway

The Signaling by EGFR pathway is catalogued in Reactome (ID: R-HSA-177929) and involves 9 genes. In the BiohacksAI corpus, 29 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADAM10, ADAM17, CDC42, CSK, EGFR.