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BiohacksAI

Evidence-Based Biohacking

Patent Pending

APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint

REACTOME PATHWAY
Reactome: R-HSA-17941935 genes27 compounds

The APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint pathway (Reactome ID: R-HSA-179419) involves 35 genes and is affected by 27 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1CCNA1CDK1NEK2PSMA1PSMA2PSMA3PSMA4PSMA5PSMA6PSMA7PSMB1PSMB2PSMB3PSMB4PSMB5PSMB6PSMB7PSMC1PSMC2PSMC3PSMC4PSMC5PSMC6PSMD1PSMD11PSMD12PSMD13PSMD14PSMD2+5 more

Compounds Affecting APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint

#CompoundTargets HitStudies
1Bortezomib—300
2Reserpine—297
3Quercetin—300
4sp600125—117
5kenpaullone—8
6alsterpaullone—12
7Apigenin 5,7,4'-trihydroxy-flavone,—300
8chrysin—300
9Luteolin 5,7,3',4'-tetrahydroxy-flavone,—150
10Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as—300
11indirubin—300
12Clofibrate—299
13Fenofibrate—297
14Sertraline—1,000
15Cinnarizine—299
16Clotrimazole—296
17Rotenone—300
18fisetin—78
19Sorafenib—300
20Disulfiram—297
214-Hydroxybenzoate-3-Monooxygenase—300
22egcg—300
23Genistein—300
24myricetin-3-O-galactopyranoside [Supplementary Concept]—300
25Vemurafenib—298
26Pioglitazone—297
27Harmaline—300

About the APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Pathway

The APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint pathway is catalogued in Reactome (ID: R-HSA-179419) and involves 35 genes. In the BiohacksAI corpus, 27 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, CCNA1, CDK1, NEK2, PSMA1.