Question 1

What compounds affect the Synthesis of bile acids and bile salts via 24-hydroxycholesterol pathway?

Accepted Answer

16 compounds in the BiohacksAI corpus have documented interactions with genes in the Synthesis of bile acids and bile salts via 24-hydroxycholesterol pathway (Reactome ID: R-HSA-193775). These compounds target 6 genes within this pathway.

Question 2

What genes are in the Synthesis of bile acids and bile salts via 24-hydroxycholesterol pathway?

Accepted Answer

The Synthesis of bile acids and bile salts via 24-hydroxycholesterol pathway involves 6 genes. Key genes include: AKR1C1, AKR1C2, AKR1C3, AKR1C4, CYP46A1, CYP8B1.

#	Compound	Targets Hit	Studies
1	Medroxyprogesterone Acetate	—	299
2	Naproxen	—	1,000
3	Berberine	—	300
4	Indomethacin	—	297
5	Linoleic Acid	—	300
6	Bimatoprost	—	297
7	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
8	chrysin	—	300
9	Progesterone	—	299
10	Testosterone	—	299
11	Equilin	—	216
12	Clotrimazole	—	296
13	Econazole	—	299
14	Miconazole	—	298
15	Voriconazole	—	299
16	Cholesterol	—	300

BiohacksAI

Synthesis of bile acids and bile salts via 24-hydroxycholesterol

Genes in this Pathway

Compounds Affecting Synthesis of bile acids and bile salts via 24-hydroxycholesterol

About the Synthesis of bile acids and bile salts via 24-hydroxycholesterol Pathway