What compounds affect the Signaling by NOTCH2 pathway?

51 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by NOTCH2 pathway (Reactome ID: R-HSA-1980145). These compounds target 9 genes within this pathway.

What genes are in the Signaling by NOTCH2 pathway?

The Signaling by NOTCH2 pathway involves 9 genes. Key genes include: ADAM10, APH1A, APH1B, CREB1, EP300, NCSTN, PSEN1, PSEN2, PSENEN.

Signaling by NOTCH2

REACTOME PATHWAY

Reactome: R-HSA-19801459 genes51 compounds

The Signaling by NOTCH2 pathway (Reactome ID: R-HSA-1980145) involves 9 genes and is affected by 51 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADAM10 APH1A APH1B CREB1 EP300 NCSTN PSEN1 PSEN2 PSENEN

Compounds Affecting Signaling by NOTCH2

#	Compound	Targets Hit	Studies
1	Dihydroergocristine	—	187
2	cycloheximide	—	300
3	Disulfiram	—	297
4	Azacitidine	—	298
5	Azacitidine	—	300
6	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
7	Levalbuterol	—	1,000
8	Adenosine Monophosphate Adenine nucleotide containing	—	300
9	Levalbuterol	—	297
10	Bortezomib	—	300
11	Clofarabine	—	298
12	Dactinomycin	—	297
13	Danazol	—	298
14	Emetine	—	298
15	Ethidium	—	300
16	Isopentenyladenosine N(6)-[delta(3)-isopentenyl]adenosine. Isopentenyl derivative of adenosine which is	—	270
17	Sulbactam	—	299
18	trequinsin hydrochloride	—	1
19	chrysin	—	300
20	Genistein	—	300
21	Quercetin	—	300
22	Testosterone	—	299
23	Ciclopirox	—	88
24	Cladribine	—	297
25	Clenbuterol	—	300
26	Corticosterone	—	300
27	Dasatinib	—	299
28	Daunorubicin	—	298
29	Dinoprostone	—	296
30	Epinephrine	—	299
31	Ethinyl Estradiol	—	300
32	Imatinib Mesylate	—	300
33	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	—	299
34	Nisoldipine	—	297
35	Nocodazole Nocodazole is	—	215
36	Masoprocol	—	300
37	Norepinephrine Precursor of epinephrine that is secreted by	—	298
38	o-Phthalaldehyde	—	300
39	Oxyphenbutazone	—	300
40	pivampicillin	—	275
41	Potassium Dichromate Chromic acid (H2Cr2O7), dipotassium salt.	—	300
42	Salmeterol Xinafoate	—	227
43	Tilorone	—	300
44	Urea	—	297
45	Bisphenol A-Glycidyl Methacrylate	—	197
46	Kaempferols	—	300
47	Progesterone	—	299
48	Hexachlorophene	—	300
49	plumbagin [Supplementary Concept]	—	300
50	egcg	—	300

About the Signaling by NOTCH2 Pathway

The Signaling by NOTCH2 pathway is catalogued in Reactome (ID: R-HSA-1980145) and involves 9 genes. In the BiohacksAI corpus, 51 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADAM10, APH1A, APH1B, CREB1, EP300.