Question 1

What compounds affect the Formation of the beta-catenin:TCF transactivating complex pathway?

Accepted Answer

27 compounds in the BiohacksAI corpus have documented interactions with genes in the Formation of the beta-catenin:TCF transactivating complex pathway (Reactome ID: R-HSA-201722). These compounds target 11 genes within this pathway.

Question 2

What genes are in the Formation of the beta-catenin:TCF transactivating complex pathway?

Accepted Answer

The Formation of the beta-catenin:TCF transactivating complex pathway involves 11 genes. Key genes include: ASH2L, CREBBP, DPY30, EP300, HDAC1, MEN1, MYC, RBBP5, TCF7L2, TERT.

#	Compound	Targets Hit	Studies
1	s adenosylhomocysteine	—	300
2	egcg	—	300
3	Vorinostat	—	299
4	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
5	scriptaid	—	53
6	Valproic Acid	—	296
7	pictilisib	—	25
8	Butyric Acid	—	300
9	Ursolic Acid	—	300
10	Celecoxib	—	295
11	Daunorubicin	—	298
12	Bortezomib	—	300
13	Camptothecin	—	300
14	Ethidium	—	300
15	Oleic Acid	—	112
16	celastrol	—	300
17	Papaverine	—	299
18	Colchicine	—	300
19	Etazolate	—	66
20	Nocodazole Nocodazole is	—	215
21	plumbagin [Supplementary Concept]	—	300
22	11-hydroxypalmatine [Supplementary Concept]	—	238
23	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
24	Nitroblue Tetrazolium Colorless to yellow dye that is reducible to blue or black formazan crystals by certain cells; formerly used to distinguish between nonbacterial and bacterial diseases,	—	300
25	Danazol	—	298
26	Methysergide	—	300
27	pnu74654	—	6

BiohacksAI

Formation of the beta-catenin:TCF transactivating complex

Genes in this Pathway

Compounds Affecting Formation of the beta-catenin:TCF transactivating complex

About the Formation of the beta-catenin:TCF transactivating complex Pathway