BETABiohacksAI is a research tool for informational purposes only. All outputs are computational hypothesis candidates — not confirmed mechanisms, not medical advice, and not a substitute for professional medical judgment. Independent experimental validation is always required.
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Methysergide

An ergot derivative that is a congener of LYSERGIC ACID DIETHYLAMIDE. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize serotonin in the carcinoid syndrome.

300+ PubMed studies analyzed · 4 RCTs · Evidence Score: 42.9

Research Domains

Methysergide has been studied across 17 research domains including 🌤️ Mood & Depression, 💊 Pain, ❤️ Cardiovascular, 🧠 Focus & Attention, 😴 Sleep. The primary research focus is 🌤️ Mood & Depression with 48% of studies addressing this area.

Similar Compounds by Shared Targets

The following compounds share molecular targets with Methysergide, based on binding affinity data from BindingDB and ChEMBL. Sorted by shared target overlap.

Methylergonovine
33 shared targets
Lysergic
25 shared targets
Yohimbine
25 shared targets
Ergotamine
23 shared targets
Pergolide
23 shared targets
Dihydroergotamine
24 shared targets
Lisuride
22 shared targets
Amitriptyline
31 shared targets
Cabergoline
18 shared targets
Metergoline
32 shared targets
Loading evidence profile...

This evidence profile for Methysergide is generated deterministically from 300 PubMed-indexed studies. All data is corpus-verified with Merkle proofs. BiohacksAI does not provide medical advice. Always consult a healthcare professional before starting any supplement regimen.

Data source: PubMed/MEDLINE (NLM). Corpus version: current. Patent pending (EVE-PAT-2026-001). © 2026 Organiq Sweden AB.