Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

Q: What compounds affect the Synthesis of Prostaglandins (PG) and Thromboxanes (TX) pathway?

82 compounds in the BiohacksAI corpus have documented interactions with genes in the Synthesis of Prostaglandins (PG) and Thromboxanes (TX) pathway (Reactome ID: R-HSA-2162123). These compounds target 8 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-21621238 genes82 compounds

The Synthesis of Prostaglandins (PG) and Thromboxanes (TX) pathway (Reactome ID: R-HSA-2162123) involves 8 genes and is affected by 82 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AKR1C3 CBR1 CYP8B1 HPGD PTGES PTGES3 PTGS2 TBXAS1

Compounds Affecting Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

#	Compound	Targets Hit	Studies
1	Indomethacin	—	297
2	Celecoxib	—	295
3	ns398	—	116
4	Naproxen	—	1,000
5	Arachidonic Acid	—	245
6	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
7	Quercetin	—	300
8	monorden	—	8
9	Niflumic Acid	—	300
10	salvin [Supplementary Concept]	—	300
11	Linoleic Acid	—	300
12	Meloxicam	—	299
13	Resveratrol	—	298
14	Etodolac	—	296
15	sulindac sulfide	—	79
16	pterostilbene	—	299
17	aphs	—	7
18	Oxaprozin	—	181
19	sc560	—	13
20	cbd	—	298
21	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	1,000
22	Ursolic Acid	—	300
23	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	293
24	Acetylcysteine	—	298
25	butein	—	158
26	Calcitriol	—	300
27	cannabidiol	—	296
28	Cephradine	—	298
29	Daunorubicin	—	298
30	Epinephrine	—	299
31	Ergotamine	—	299
32	Hesperidin	—	300
33	Indapamide	—	299
34	isoetharine	—	112
35	Lymecycline	—	143
36	Methyldopa	—	297
37	Norepinephrine Precursor of epinephrine that is secreted by	—	298
38	Noscapine	—	300
39	Oxymetazoline	—	298
40	Oxymetholone	—	298
41	Phenylbutazone	—	300
42	Procarbazine	—	299
43	Rifaximin	—	298
44	Rolitetracycline	—	166
45	Sorafenib	—	300
46	Sulindac	—	297
47	Tigecycline	—	299
48	tiopronin	—	299
49	Tolmetin	—	298
50	Tripterygium	—	300

About the Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Pathway

The Synthesis of Prostaglandins (PG) and Thromboxanes (TX) pathway is catalogued in Reactome (ID: R-HSA-2162123) and involves 8 genes. In the BiohacksAI corpus, 82 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AKR1C3, CBR1, CYP8B1, HPGD, PTGES.