What compounds affect the ECM proteoglycans pathway?

32 compounds in the BiohacksAI corpus have documented interactions with genes in the ECM proteoglycans pathway (Reactome ID: R-HSA-3000178). These compounds target 7 genes within this pathway.

What genes are in the ECM proteoglycans pathway?

The ECM proteoglycans pathway involves 7 genes. Key genes include: APP, ITGA2B, ITGAV, ITGB3, MUSK, PTPRS, SERPINE1.

ECM proteoglycans

REACTOME PATHWAY

Reactome: R-HSA-30001787 genes32 compounds

The ECM proteoglycans pathway (Reactome ID: R-HSA-3000178) involves 7 genes and is affected by 32 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

APP ITGA2B ITGAV ITGB3 MUSK PTPRS SERPINE1

Compounds Affecting ECM proteoglycans

#	Compound	Targets Hit	Studies
1	Tirofiban Tyrosine analog and PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX antagonist that inhibits PLATELET AGGREGATION and is used in	—	299
2	egcg	—	300
3	Resveratrol	—	298
4	Quercetin	—	300
5	Hesperidin	—	300
6	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
7	Kaempferols	—	300
8	Methylene Blue	—	200
9	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
10	(N-methyl-C-11)-2-(4-methylamino-phenyl)-6-hydroxybenzothiazole [Supplementary Concept] neutral analog of amyloid-binding thioflavin-T (BTA) that crosses	—	300
11	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
12	caffeic acid	—	300
13	Vitamin	—	295
14	2-Methoxyestradiol	—	300
15	arctigenin-4-O-(3''-O-acetyl-beta-D-glucoside) [Supplementary Concept] isolated from	—	300
16	Cladribine	—	297
17	Digitoxin	—	300
18	Digoxin	—	299
19	Disulfiram	—	297
20	Edetic Acid	—	24
21	Catechin	—	300
22	Vanillic Acid	—	300
23	Ouabain	—	300
24	Podophyllotoxin	—	14
25	Quinic Acid	—	218
26	Retinaldehyde	—	300
27	streptonigrin	—	299
28	Trifluridine	—	295
29	Hexachlorophene	—	300
30	Sorafenib	—	300
31	Crizotinib	—	298
32	scutellarein	—	113

About the ECM proteoglycans Pathway

The ECM proteoglycans pathway is catalogued in Reactome (ID: R-HSA-3000178) and involves 7 genes. In the BiohacksAI corpus, 32 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include APP, ITGA2B, ITGAV, ITGB3, MUSK.