What genes are in the Detoxification of Reactive Oxygen Species pathway?

The Detoxification of Reactive Oxygen Species pathway involves 10 genes. Key genes include: CYBB, GPX1, GSR, GSTP1, NCF1, NOX4, NOX5, P4HB, PRDX1, SOD1.

Detoxification of Reactive Oxygen Species

Q: What compounds affect the Detoxification of Reactive Oxygen Species pathway?

42 compounds in the BiohacksAI corpus have documented interactions with genes in the Detoxification of Reactive Oxygen Species pathway (Reactome ID: R-HSA-3299685). These compounds target 10 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-329968510 genes42 compounds

The Detoxification of Reactive Oxygen Species pathway (Reactome ID: R-HSA-3299685) involves 10 genes and is affected by 42 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CYBB GPX1 GSR GSTP1 NCF1 NOX4 NOX5 P4HB PRDX1 SOD1

Compounds Affecting Detoxification of Reactive Oxygen Species

#	Compound	Targets Hit	Studies
1	celastrol	—	300
2	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
3	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
4	Methylene Blue	—	200
5	amlexanox	—	96
6	DEAD-box RNA Helicases	—	169
7	Thioctic Acid	—	298
8	vinpocetine	—	299
9	cefatrizine	—	114
10	Cefazolin	—	300
11	Cefdinir	—	298
12	Cefixime	—	300
13	Cefmenoxime	—	300
14	Cefotetan	—	299
15	Cefoxitin	—	300
16	Cefpodoxime	—	299
17	Cefprozil	—	297
18	ceftazidime	—	300
19	Ceftibuten	—	299
20	Cephaloglycin	—	102
21	Dipyrone	—	298
22	Dithiazanine 3-Ethyl-2-(5-(3-ethyl-2-benzothiazolinylidene)-1,3- pentadienyl)benzothiazolium.	—	135
23	Doxazosin	—	24
24	Irinotecan	—	298
25	silver sulfadiazine	—	299
26	stx64	—	2
27	Thioctic Acid	—	300
28	chrysin	—	300
29	Naloxone	—	299
30	Kaempferols	—	300
31	Quercetin	—	300
32	Doxycycline	—	999
33	Oxytetracycline	—	300
34	Tetracycline	—	300
35	Carmustine	—	297
36	Meloxicam	—	299
37	indirubin	—	300
38	Loxapine	—	30
39	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
40	Equilin	—	216
41	Vitamin E	—	300
42	piericidin	—	32

About the Detoxification of Reactive Oxygen Species Pathway

The Detoxification of Reactive Oxygen Species pathway is catalogued in Reactome (ID: R-HSA-3299685) and involves 10 genes. In the BiohacksAI corpus, 42 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CYBB, GPX1, GSR, GSTP1, NCF1.