What compounds affect the Notch-HLH transcription pathway pathway?

81 compounds in the BiohacksAI corpus have documented interactions with genes in the Notch-HLH transcription pathway pathway (Reactome ID: R-HSA-350054). These compounds target 16 genes within this pathway.

What genes are in the Notch-HLH transcription pathway pathway?

The Notch-HLH transcription pathway pathway involves 16 genes. Key genes include: CREBBP, HDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7.

Notch-HLH transcription pathway

REACTOME PATHWAY

Reactome: R-HSA-35005416 genes81 compounds

The Notch-HLH transcription pathway pathway (Reactome ID: R-HSA-350054) involves 16 genes and is affected by 81 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CREBBP HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 KAT2A KAT2B NCOR1 NCOR2

Compounds Affecting Notch-HLH transcription pathway

#	Compound	Targets Hit	Studies
1	Vorinostat	—	299
2	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
3	scriptaid	—	53
4	pictilisib	—	25
5	Valproic Acid	—	296
6	Butyric Acid	—	300
7	Ursolic Acid	—	300
8	Camptothecin	—	300
9	Celecoxib	—	295
10	Daunorubicin	—	298
11	Chlorogenic Acid	—	300
12	gamma-Aminobutyric Acid	—	300
13	Bortezomib	—	300
14	Genistein	—	300
15	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
16	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
17	Pueraria	—	300
18	Kaempferols	—	300
19	Quercetin	—	300
20	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
21	chrysin	—	300
22	Axitinib	—	298
23	Febuxostat	—	297
24	Nocodazole Nocodazole is	—	215
25	Iodoacetamide	—	300
26	Bufexamac	—	137
27	Resveratrol	—	298
28	Carboxin	—	174
29	Leflunomide	—	297
30	Linuron	—	299
31	Niclosamide	—	299
32	Methylene Blue	—	200
33	amlexanox	—	96
34	Anthraquinones Compounds based on ANTHRACENES which contain two KETONES in	—	300
35	2-Acetylaminofluorene	—	300
36	diethylhydroxylamine	—	21
37	felbinac	—	31
38	Gemfibrozil	—	297
39	Niflumic Acid	—	300
40	Oxyphenbutazone	—	300
41	Riluzole	—	298
42	thiophanate	—	300
43	fisetin	—	78
44	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
45	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
46	pterostilbene	—	299
47	butein	—	158
48	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
49	Hesperidin	—	300
50	pd98059	—	7

About the Notch-HLH transcription pathway Pathway

The Notch-HLH transcription pathway pathway is catalogued in Reactome (ID: R-HSA-350054) and involves 16 genes. In the BiohacksAI corpus, 81 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CREBBP, HDAC1, HDAC10, HDAC11, HDAC2.