What compounds affect the Metabolism of serotonin pathway?

36 compounds in the BiohacksAI corpus have documented interactions with genes in the Metabolism of serotonin pathway (Reactome ID: R-HSA-380612). These compounds target 2 genes within this pathway.

What genes are in the Metabolism of serotonin pathway?

The Metabolism of serotonin pathway involves 2 genes. Key genes include: ALDH2, MAOA.

Metabolism of serotonin

REACTOME PATHWAY

Reactome: R-HSA-3806122 genes36 compounds

The Metabolism of serotonin pathway (Reactome ID: R-HSA-380612) involves 2 genes and is affected by 36 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ALDH2 MAOA

Compounds Affecting Metabolism of serotonin

#	Compound	Targets Hit	Studies
1	Iproniazid	—	300
2	Moclobemide	—	299
3	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
4	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
5	Quercetin	—	300
6	Phenelzine	—	297
7	Genistein	—	300
8	Idazoxan	—	300
9	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
10	Harmaline	—	300
11	hispidol	—	13
12	Linezolid	—	298
13	Vitamin K 3	—	300
14	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	—	300
15	chrysin	—	300
16	Methylene Blue	—	200
17	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
18	plumbagin [Supplementary Concept]	—	300
19	Sirolimus	—	300
20	Rutin	—	300
21	Aripiprazole	—	298
22	auraptene	—	148
23	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
24	Famotidine	—	296
25	Fentanyl	—	300
26	Guanabenz	—	298
27	Guanfacine	—	294
28	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
29	Lynestrenol	—	299
30	1-(5,8-dihydro-1,4-dihydroxy-5,8-dioxo-2-naphthyl)-4-methylpent-3-en-1-yl cinnamate [Supplementary Concept]	—	54
31	pentamidine	—	299
32	Rilmenidine Oxazole derivative that acts as	—	300
33	Sorafenib	—	300
34	Pueraria	—	300
35	Disulfiram	—	297
36	prunetin	—	35

About the Metabolism of serotonin Pathway

The Metabolism of serotonin pathway is catalogued in Reactome (ID: R-HSA-380612) and involves 2 genes. In the BiohacksAI corpus, 36 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ALDH2, MAOA.