What compounds affect the Prostanoid ligand receptors pathway?

57 compounds in the BiohacksAI corpus have documented interactions with genes in the Prostanoid ligand receptors pathway (Reactome ID: R-HSA-391908). These compounds target 8 genes within this pathway.

What genes are in the Prostanoid ligand receptors pathway?

The Prostanoid ligand receptors pathway involves 8 genes. Key genes include: PTGDR, PTGDR2, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R.

Prostanoid ligand receptors

REACTOME PATHWAY

Reactome: R-HSA-3919088 genes57 compounds

The Prostanoid ligand receptors pathway (Reactome ID: R-HSA-391908) involves 8 genes and is affected by 57 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

PTGDR PTGDR2 PTGER1 PTGER2 PTGER4 PTGFR PTGIR TBXA2R

Compounds Affecting Prostanoid ligand receptors

#	Compound	Targets Hit	Studies
1	Dinoprostone	—	296
2	Dinoprost	—	252
3	Prostaglandin D2	—	300
4	Alprostadil	—	297
5	Iloprost	—	300
6	Cloprostenol	—	300
7	Epoprostenol	—	297
8	Misoprostol	—	298
9	Celecoxib	—	295
10	Calcimycin	—	216
11	Disulfiram	—	297
12	Vitamin K 3	—	300
13	Nitroarginine	—	300
14	Methylene Blue	—	200
15	plumbagin [Supplementary Concept]	—	300
16	Levalbuterol	—	1,000
17	Levalbuterol	—	297
18	Carvedilol	—	296
19	celastrol	—	300
20	Cetylpyridinium Cationic bactericidal surfactant used as	—	300
21	Cyclic AMP	—	300
22	Cyclic AMP	—	300
23	Hexachlorophene	—	300
24	Metaproterenol	—	298
25	Norepinephrine Precursor of epinephrine that is secreted by	—	298
26	Noscapine	—	300
27	p-Azobenzenearsonate	—	91
28	Salmeterol Xinafoate	—	227
29	Silymarin	—	300
30	trequinsin hydrochloride	—	1
31	Aripiprazole	—	298
32	Amlodipine	—	1,000
33	cbd	—	298
34	Losartan	—	1,000
35	Simvastatin	—	1,000
36	Axitinib	—	298
37	candesartan cilexetil [Supplementary Concept]	—	300
38	cannabidiol	—	296
39	Enoxacin	—	299
40	Epirubicin	—	300
41	Ezetimibe	—	296
42	Flutamide	—	298
43	Irbesartan	—	298
44	Micafungin	—	300
45	Nicergoline	—	300
46	Norethindrone Acetate Acetate ester of norethindrone that is used as	—	300
47	Pioglitazone	—	297
48	Rifamycins	—	300
49	Rifamycins	—	300
50	Ritonavir	—	298

About the Prostanoid ligand receptors Pathway

The Prostanoid ligand receptors pathway is catalogued in Reactome (ID: R-HSA-391908) and involves 8 genes. In the BiohacksAI corpus, 57 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include PTGDR, PTGDR2, PTGER1, PTGER2, PTGER4.