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Silymarin

A mixture of flavonoids extracted from seeds of the MILK THISTLE, Silybum marianum. It consists primarily of silybin and its isomers, silicristin and silidianin. Silymarin displays antioxidant and membrane stabilizing activity. It protects various tissues and organs against chemical injury, and shows potential as an antihepatoxic agent.

464+ PubMed studies analyzed · 19 RCTs · Evidence Score: 48.7

Research Domains

Silymarin has been studied across 19 research domains including 🫁 Liver & Detox, 🔬 Inflammation, 🔬 Oncology, 🔥 Metabolic, 🧘 Stress & Anxiety. The primary research focus is 🫁 Liver & Detox with 40% of studies addressing this area.

Similar Compounds by Shared Targets

The following compounds share molecular targets with Silymarin, based on binding affinity data from BindingDB and ChEMBL. Sorted by shared target overlap.

canavanine
2 shared targets
paxilline
3 shared targets
Cholecalciferol
3 shared targets
Flunarizine
2 shared targets
Etazolate
2 shared targets
Vidarabine
2 shared targets
alphitonin
2 shared targets
Butaclamol
2 shared targets
Carbidopa
2 shared targets
daph
3 shared targets
Loading evidence profile...

This evidence profile for Silymarin is generated deterministically from 464 PubMed-indexed studies. All data is corpus-verified with Merkle proofs. BiohacksAI does not provide medical advice. Always consult a healthcare professional before starting any supplement regimen.

Data source: PubMed/MEDLINE (NLM). Corpus version: current. Patent pending (EVE-PAT-2026-001). © 2026 Organiq Sweden AB.