What compounds affect the Platelet calcium homeostasis pathway?

23 compounds in the BiohacksAI corpus have documented interactions with genes in the Platelet calcium homeostasis pathway (Reactome ID: R-HSA-418360). These compounds target 8 genes within this pathway.

What genes are in the Platelet calcium homeostasis pathway?

The Platelet calcium homeostasis pathway involves 8 genes. Key genes include: ATP2A1, ATP2A2, ATP2A3, P2RX1, P2RX3, P2RX4, P2RX7, TRPC6.

Platelet calcium homeostasis

REACTOME PATHWAY

Reactome: R-HSA-4183608 genes23 compounds

The Platelet calcium homeostasis pathway (Reactome ID: R-HSA-418360) involves 8 genes and is affected by 23 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ATP2A1 ATP2A2 ATP2A3 P2RX1 P2RX3 P2RX4 P2RX7 TRPC6

Compounds Affecting Platelet calcium homeostasis

#	Compound	Targets Hit	Studies
1	Adenosine Triphosphate	—	300
2	Suramin	—	300
3	paxilline	—	42
4	Hyoscyamine	—	296
5	Carvedilol	—	296
6	Propantheline	—	73
7	Methylene Blue	—	200
8	Hexachlorophene	—	300
9	Promazine	—	40
10	Promethazine	—	121
11	propionylpromazine hydrochloride	—	2
12	Thioridazine	—	35
13	triflupromazine hydrochloride	—	12
14	Arachidonic Acid	—	245
15	Duloxetine Hydrochloride	—	993
16	Amoxapine	—	259
17	Fluspirilene	—	74
18	Lysophosphatidylcholines Derivatives of PHOSPHATIDYLCHOLINES obtained by their partial hydrolysis which removes	—	300
19	Pyridoxal Phosphate This is	—	300
20	Adenosine Diphosphate Adenosine 5'-(trihydrogen diphosphate).	—	300
21	Progesterone	—	299
22	oxatomide [Supplementary Concept] structure;	—	128
23	Thapsigargin	—	300

About the Platelet calcium homeostasis Pathway

The Platelet calcium homeostasis pathway is catalogued in Reactome (ID: R-HSA-418360) and involves 8 genes. In the BiohacksAI corpus, 23 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ATP2A1, ATP2A2, ATP2A3, P2RX1, P2RX3.