ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
REACTOME PATHWAYThe ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression pathway (Reactome ID: R-HSA-427389) involves 3 genes and is affected by 19 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Vorinostat | — | 299 |
| 2 | trichostatic acid [Supplementary Concept] related to trichostatin | — | 300 |
| 3 | scriptaid | — | 53 |
| 4 | Valproic Acid | — | 296 |
| 5 | pictilisib | — | 25 |
| 6 | Butyric Acid | — | 300 |
| 7 | Ursolic Acid | — | 300 |
| 8 | Celecoxib | — | 295 |
| 9 | Daunorubicin | — | 298 |
| 10 | Bortezomib | — | 300 |
| 11 | Camptothecin | — | 300 |
| 12 | Disulfiram | — | 297 |
| 13 | s adenosylhomocysteine | — | 300 |
| 14 | Cyproheptadine | — | 299 |
| 15 | Gliotoxin | — | 300 |
| 16 | Glutathione | — | 300 |
| 17 | Anthraquinones Compounds based on ANTHRACENES which contain two KETONES in | — | 300 |
| 18 | Dimethyl Sulfoxide | — | 300 |
| 19 | ninhydrin | — | 300 |
About the ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Pathway
The ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression pathway is catalogued in Reactome (ID: R-HSA-427389) and involves 3 genes. In the BiohacksAI corpus, 19 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include EHMT2, HDAC1, HDAC2.