Question 1

What compounds affect the Smooth Muscle Contraction pathway?

Accepted Answer

27 compounds in the BiohacksAI corpus have documented interactions with genes in the Smooth Muscle Contraction pathway (Reactome ID: R-HSA-445355). These compounds target 12 genes within this pathway.

Question 2

What genes are in the Smooth Muscle Contraction pathway?

Accepted Answer

The Smooth Muscle Contraction pathway involves 12 genes. Key genes include: ALDH2, ANXA2, CACNA1G, CACNA1H, CACNA1I, GUCY1A1, GUCY1A2, GUCY1B1, MYLK, PDE5A.

#	Compound	Targets Hit	Studies
1	Flunarizine Flunarizine is	—	299
2	Benzydamine	—	298
3	Ergosterol	—	300
4	oxatomide [Supplementary Concept] structure;	—	128
5	Ethosuximide	—	297
6	Astemizole Antihistamine drug now withdrawn from	—	280
7	Calcimycin	—	216
8	Danazol	—	298
9	Estriol	—	300
10	Ezetimibe	—	296
11	Hexachlorophene	—	300
12	Loratadine	—	296
13	Metergoline	—	144
14	Nicardipine	—	94
15	Oxytetracycline	—	300
16	Ritonavir	—	298
17	Wortmannin	—	300
18	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
19	hydroxyfasudil [Supplementary Concept]	—	11
20	sp600125	—	117
21	Pueraria	—	300
22	Disulfiram	—	297
23	prunetin	—	35
24	Sildenafil Citrate	—	300
25	Epimedium	—	300
26	Papaverine	—	299
27	Ethylmaleimide	—	300

BiohacksAI

Smooth Muscle Contraction

Genes in this Pathway

Compounds Affecting Smooth Muscle Contraction

About the Smooth Muscle Contraction Pathway