PINK1-PRKN Mediated Mitophagy
REACTOME PATHWAYThe PINK1-PRKN Mediated Mitophagy pathway (Reactome ID: R-HSA-5205685) involves 5 genes and is affected by 24 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting PINK1-PRKN Mediated Mitophagy
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Novobiocin | — | 300 |
| 2 | naringin | — | 300 |
| 3 | Chlorhexidine | — | 299 |
| 4 | Perphenazine | — | 297 |
| 5 | Sphingosine | — | 300 |
| 6 | Resveratrol | — | 298 |
| 7 | Sertraline | — | 1,000 |
| 8 | Astemizole Antihistamine drug now withdrawn from | — | 280 |
| 9 | Canrenone | — | 300 |
| 10 | Thioridazine | — | 35 |
| 11 | Apigenin 5,7,4'-trihydroxy-flavone, | — | 300 |
| 12 | kenpaullone | — | 8 |
| 13 | Genistein | — | 300 |
| 14 | amn082 | — | 29 |
| 15 | Hexachlorophene | — | 300 |
| 16 | Medroxyprogesterone Acetate | — | 299 |
| 17 | Nitrendipine | — | 299 |
| 18 | Fluspirilene | — | 74 |
| 19 | Mestranol | — | 300 |
| 20 | Tolazamide | — | 169 |
| 21 | Trifluridine | — | 295 |
| 22 | amlexanox | — | 96 |
| 23 | Axitinib | — | 298 |
| 24 | Crizotinib | — | 298 |
About the PINK1-PRKN Mediated Mitophagy Pathway
The PINK1-PRKN Mediated Mitophagy pathway is catalogued in Reactome (ID: R-HSA-5205685) and involves 5 genes. In the BiohacksAI corpus, 24 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include MAP1LC3A, MAP1LC3B, PRKN, TBK1, UBE2N.