Regulation of TNFR1 signaling
REACTOME PATHWAYThe Regulation of TNFR1 signaling pathway (Reactome ID: R-HSA-5357905) involves 7 genes and is affected by 11 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Regulation of TNFR1 signaling
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Crizotinib | — | 298 |
| 2 | chicoric acid | — | 117 |
| 3 | amlexanox | — | 96 |
| 4 | alsterpaullone | — | 12 |
| 5 | Aurintricarboxylic Acid | — | 184 |
| 6 | sp600125 | — | 117 |
| 7 | Axitinib | — | 298 |
| 8 | Adenosine Triphosphate | — | 300 |
| 9 | Afatinib | — | 297 |
| 10 | glaucarubinone | — | 10 |
| 11 | Gliotoxin | — | 300 |
About the Regulation of TNFR1 signaling Pathway
The Regulation of TNFR1 signaling pathway is catalogued in Reactome (ID: R-HSA-5357905) and involves 7 genes. In the BiohacksAI corpus, 11 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CHUK, IKBKB, IKBKE, MAPKAPK2, RBCK1.