What genes are in the Dectin-1 mediated noncanonical NF-kB signaling pathway?

The Dectin-1 mediated noncanonical NF-kB signaling pathway involves 38 genes. Key genes include: ADRM1, CHUK, CUL1, NFKB2, PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6.

Dectin-1 mediated noncanonical NF-kB signaling

Q: What compounds affect the Dectin-1 mediated noncanonical NF-kB signaling pathway?

38 compounds in the BiohacksAI corpus have documented interactions with genes in the Dectin-1 mediated noncanonical NF-kB signaling pathway (Reactome ID: R-HSA-5607761). These compounds target 38 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-560776138 genes38 compounds

The Dectin-1 mediated noncanonical NF-kB signaling pathway (Reactome ID: R-HSA-5607761) involves 38 genes and is affected by 38 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 CHUK CUL1 NFKB2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2+8 more

Compounds Affecting Dectin-1 mediated noncanonical NF-kB signaling

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Quercetin	—	300
4	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
5	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
6	Resveratrol	—	298
7	Podophyllotoxin	—	14
8	Kaempferols	—	300
9	Rutin	—	300
10	Withania	—	500
11	chicoric acid	—	117
12	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
13	tamarixetin	—	26
14	withaferin	—	300
15	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
16	candesartan cilexetil [Supplementary Concept]	—	300
17	Voriconazole	—	299
18	Cathelicidins Antimicrobial cationic peptides with	—	300
19	plumbagin [Supplementary Concept]	—	300
20	Ursolic Acid	—	300
21	Oleanolic Acid	—	300
22	pyrrolidine dithiocarbamate	—	275
23	Trifluridine	—	295
24	vinblastine sulfate	—	81
25	Disulfiram	—	297
26	4-Hydroxybenzoate-3-Monooxygenase	—	300
27	chrysin	—	300
28	egcg	—	300
29	Genistein	—	300
30	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
31	Amlodipine	—	1,000
32	piceatannol	—	300
33	sp600125	—	117
34	Cetylpyridinium Cationic bactericidal surfactant used as	—	300
35	ninhydrin	—	300
36	Pioglitazone	—	297
37	Harmaline	—	300
38	glaucarubinone	—	10

About the Dectin-1 mediated noncanonical NF-kB signaling Pathway

The Dectin-1 mediated noncanonical NF-kB signaling pathway is catalogued in Reactome (ID: R-HSA-5607761) and involves 38 genes. In the BiohacksAI corpus, 38 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, CHUK, CUL1, NFKB2, PSMA1.