RHO GTPases Activate ROCKs
REACTOME PATHWAYThe RHO GTPases Activate ROCKs pathway (Reactome ID: R-HSA-5627117) involves 5 genes and is affected by 16 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting RHO GTPases Activate ROCKs
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Crizotinib | — | 298 |
| 2 | kenpaullone | — | 8 |
| 3 | Sorafenib | — | 300 |
| 4 | Dasatinib | — | 299 |
| 5 | hydroxyfasudil [Supplementary Concept] | — | 11 |
| 6 | Kinetin | — | 300 |
| 7 | alsterpaullone | — | 12 |
| 8 | Edaravone | — | 298 |
| 9 | sp600125 | — | 117 |
| 10 | Sertraline | — | 1,000 |
| 11 | Cinnarizine | — | 299 |
| 12 | Clofibrate | — | 299 |
| 13 | Clotrimazole | — | 296 |
| 14 | Fenofibrate | — | 297 |
| 15 | Rotenone | — | 300 |
| 16 | Atorvastatin | — | 1,000 |
About the RHO GTPases Activate ROCKs Pathway
The RHO GTPases Activate ROCKs pathway is catalogued in Reactome (ID: R-HSA-5627117) and involves 5 genes. In the BiohacksAI corpus, 16 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CFL1, LIMK1, LIMK2, RHOC, ROCK2.