What compounds affect the Defective ABCB11 causes PFIC2 and BRIC2 pathway?

47 compounds in the BiohacksAI corpus have documented interactions with genes in the Defective ABCB11 causes PFIC2 and BRIC2 pathway (Reactome ID: R-HSA-5678520). These compounds target 1 genes within this pathway.

What genes are in the Defective ABCB11 causes PFIC2 and BRIC2 pathway?

The Defective ABCB11 causes PFIC2 and BRIC2 pathway involves 1 genes. Key genes include: ABCB11.

Defective ABCB11 causes PFIC2 and BRIC2

REACTOME PATHWAY

Reactome: R-HSA-56785201 genes47 compounds

The Defective ABCB11 causes PFIC2 and BRIC2 pathway (Reactome ID: R-HSA-5678520) involves 1 genes and is affected by 47 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCB11

Compounds Affecting Defective ABCB11 causes PFIC2 and BRIC2

#	Compound	Targets Hit	Studies
1	Glyburide	—	298
2	Pioglitazone	—	297
3	Troglitazone	—	299
4	Ritonavir	—	298
5	Taurocholic Acid	—	300
6	17 alpha-Hydroxyprogesterone Caproate Hydroxyprogesterone derivative that acts as	—	287
7	Reserpine	—	297
8	Rifamycins	—	300
9	Rifamycins	—	300
10	Sorafenib	—	300
11	Losartan	—	1,000
12	Irbesartan	—	298
13	Taurochenodeoxycholic Acid	—	300
14	Valinomycin	—	300
15	Progesterone	—	299
16	Sirolimus	—	300
17	Clotrimazole	—	296
18	Glycochenodeoxycholic Acid	—	300
19	Simvastatin	—	1,000
20	Astemizole Antihistamine drug now withdrawn from	—	280
21	Axitinib	—	298
22	beta Carotene	—	299
23	Bromocriptine	—	299
24	Chenodeoxycholic Acid	—	299
25	Cholic Acid	—	299
26	Danazol	—	298
27	Dicloxacillin	—	297
28	Digitoxin	—	300
29	Disulfiram	—	297
30	Econazole	—	299
31	Ethinyl Estradiol	—	300
32	Everolimus	—	297
33	Flunarizine Flunarizine is	—	299
34	Fusidic Acid	—	300
35	Halcinonide	—	88
36	Megestrol Acetate Megestrol acetate is	—	300
37	Metergoline	—	144
38	Miconazole	—	298
39	Mometasone Furoate	—	292
40	Nisoldipine	—	297
41	Olmesartan Medoxomil	—	300
42	Papaverine	—	299
43	Penicillin G	—	298
44	Piperonyl Butoxide	—	300
45	Rimonabant	—	300
46	Rotenone	—	300
47	Ursodeoxycholic Acid	—	298

About the Defective ABCB11 causes PFIC2 and BRIC2 Pathway

The Defective ABCB11 causes PFIC2 and BRIC2 pathway is catalogued in Reactome (ID: R-HSA-5678520) and involves 1 genes. In the BiohacksAI corpus, 47 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCB11.