What genes are in the HDR through Homologous Recombination (HRR) pathway?

The HDR through Homologous Recombination (HRR) pathway involves 14 genes. Key genes include: ATM, BARD1, BLM, BRCA1, CHEK1, DNA2, MUS81, PCNA, POLH, POLK.

HDR through Homologous Recombination (HRR)

Q: What compounds affect the HDR through Homologous Recombination (HRR) pathway?

92 compounds in the BiohacksAI corpus have documented interactions with genes in the HDR through Homologous Recombination (HRR) pathway (Reactome ID: R-HSA-5685942). These compounds target 14 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-568594214 genes92 compounds

The HDR through Homologous Recombination (HRR) pathway (Reactome ID: R-HSA-5685942) involves 14 genes and is affected by 92 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ATM BARD1 BLM BRCA1 CHEK1 DNA2 MUS81 PCNA POLH POLK RAD51 RBBP8 SEM1 WRN

Compounds Affecting HDR through Homologous Recombination (HRR)

#	Compound	Targets Hit	Studies
1	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
2	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
3	Levodopa	—	297
4	streptonigrin	—	299
5	Quercetin	—	300
6	Ethidium	—	300
7	alpha-Linolenic Acid	—	300
8	Masoprocol	—	300
9	Idarubicin	—	299
10	Norepinephrine Precursor of epinephrine that is secreted by	—	298
11	Aurintricarboxylic Acid	—	184
12	Oxytetracycline	—	300
13	rafoxanide	—	172
14	Methotrexate	—	289
15	Hexachlorophene	—	300
16	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
17	gamma-Linolenic Acid	—	300
18	piceatannol	—	300
19	Cefixime	—	300
20	Daunorubicin	—	298
21	Diiodotyrosine	—	300
22	Methyldopa	—	297
23	DEAD-box RNA Helicases	—	169
24	Thioctic Acid	—	298
25	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
26	Resveratrol	—	298
27	Ampicillin Semi-synthetic derivative of penicillin that functions as	—	294
28	Cefotetan	—	299
29	Dihydroxyphenylalanine	—	300
30	Estramustine	—	300
31	Thioctic Acid	—	300
32	Astemizole Antihistamine drug now withdrawn from	—	280
33	Azacitidine	—	298
34	Azacitidine	—	300
35	Calcimycin	—	216
36	Chlorhexidine	—	299
37	Ciclopirox	—	88
38	Colchicine	—	300
39	colchine	—	2
40	cycloheximide	—	300
41	Cytarabine	—	297
42	Demecolcine	—	246
43	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
44	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
45	dihydrorotenone	—	13
46	Fluspirilene	—	74
47	gedunin	—	54
48	lidoflazine	—	278
49	Melphalan	—	300
50	Niclosamide	—	299

About the HDR through Homologous Recombination (HRR) Pathway

The HDR through Homologous Recombination (HRR) pathway is catalogued in Reactome (ID: R-HSA-5685942) and involves 14 genes. In the BiohacksAI corpus, 92 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ATM, BARD1, BLM, BRCA1, CHEK1.