What compounds affect the UCH proteinases pathway?

72 compounds in the BiohacksAI corpus have documented interactions with genes in the UCH proteinases pathway (Reactome ID: R-HSA-5689603). These compounds target 40 genes within this pathway.

What genes are in the UCH proteinases pathway?

The UCH proteinases pathway involves 40 genes. Key genes include: ADRM1, BAP1, BARD1, NEDD8, PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6.

UCH proteinases

REACTOME PATHWAY

Reactome: R-HSA-568960340 genes72 compounds

The UCH proteinases pathway (Reactome ID: R-HSA-5689603) involves 40 genes and is affected by 72 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 BAP1 BARD1 NEDD8 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2+10 more

Compounds Affecting UCH proteinases

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
4	Calcimycin	—	216
5	Niclosamide	—	299
6	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
7	piceatannol	—	300
8	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
9	streptonigrin	—	299
10	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
11	Quercetin	—	300
12	Dasatinib	—	299
13	Methotrexate	—	289
14	Astemizole Antihistamine drug now withdrawn from	—	280
15	Azacitidine	—	298
16	Azacitidine	—	300
17	Chlorhexidine	—	299
18	Ciclopirox	—	88
19	Colchicine	—	300
20	colchine	—	2
21	cycloheximide	—	300
22	Cytarabine	—	297
23	Demecolcine	—	246
24	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
25	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
26	dihydrorotenone	—	13
27	Fluspirilene	—	74
28	gedunin	—	54
29	Hexachlorophene	—	300
30	lidoflazine	—	278
31	Melphalan	—	300
32	Nocodazole Nocodazole is	—	215
33	paxilline	—	42
34	Podophyllotoxin	—	14
35	rafoxanide	—	172
36	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
37	Trifluridine	—	295
38	Tubercidin	—	300
39	vinblastine sulfate	—	81
40	Resveratrol	—	298
41	amlexanox	—	96
42	tyrphostin ag 1295	—	1
43	Leflunomide	—	297
44	Carnitine	—	300
45	Methylene Blue	—	200
46	Carbidopa	—	298
47	Deferoxamine Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as	—	296
48	Edaravone	—	298
49	Ethidium	—	300
50	Lithocholic Acid	—	300

About the UCH proteinases Pathway

The UCH proteinases pathway is catalogued in Reactome (ID: R-HSA-5689603) and involves 40 genes. In the BiohacksAI corpus, 72 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, BAP1, BARD1, NEDD8, PSMA1.