Formation of TC-NER Pre-Incision Complex
REACTOME PATHWAYThe Formation of TC-NER Pre-Incision Complex pathway (Reactome ID: R-HSA-6781823) involves 5 genes and is affected by 13 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Formation of TC-NER Pre-Incision Complex
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | DEAD-box RNA Helicases | — | 169 |
| 2 | Thioctic Acid | — | 298 |
| 3 | Sphingosine | — | 300 |
| 4 | Thioctic Acid | — | 300 |
| 5 | alpha-Linolenic Acid | — | 300 |
| 6 | Luteolin 5,7,3',4'-tetrahydroxy-flavone, | — | 150 |
| 7 | Quercetin | — | 300 |
| 8 | celastrol | — | 300 |
| 9 | hydroxyfasudil [Supplementary Concept] | — | 11 |
| 10 | pictilisib | — | 25 |
| 11 | Sorafenib | — | 300 |
| 12 | ninhydrin | — | 300 |
| 13 | Tripterygium | — | 300 |
About the Formation of TC-NER Pre-Incision Complex Pathway
The Formation of TC-NER Pre-Incision Complex pathway is catalogued in Reactome (ID: R-HSA-6781823) and involves 5 genes. In the BiohacksAI corpus, 13 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CDK7, COPS5, ERCC3, RBX1, USP7.