Negative regulation of MET activity
REACTOME PATHWAYThe Negative regulation of MET activity pathway (Reactome ID: R-HSA-6807004) involves 5 genes and is affected by 27 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Negative regulation of MET activity
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | celastrol | — | 300 |
| 2 | Oleanolic Acid | — | 300 |
| 3 | Ursolic Acid | — | 300 |
| 4 | Lithocholic Acid | — | 300 |
| 5 | prunetin | — | 35 |
| 6 | Quercetin | — | 300 |
| 7 | Okadaic Acid | — | 300 |
| 8 | caffeic acid | — | 300 |
| 9 | Chlorogenic Acid | — | 300 |
| 10 | Methylene Blue | — | 200 |
| 11 | Oleic Acid | — | 112 |
| 12 | Mepentol [Supplementary Concept] | — | 184 |
| 13 | Evans Blue | — | 300 |
| 14 | Palmitic Acid | — | 300 |
| 15 | Suramin | — | 300 |
| 16 | vanadates | — | 284 |
| 17 | Crizotinib | — | 298 |
| 18 | Afatinib | — | 297 |
| 19 | egcg | — | 300 |
| 20 | Axitinib | — | 298 |
| 21 | Sorafenib | — | 300 |
| 22 | Adenosine Triphosphate | — | 300 |
| 23 | sp600125 | — | 117 |
| 24 | Luteolin 5,7,3',4'-tetrahydroxy-flavone, | — | 150 |
| 25 | Adapalene | — | 296 |
| 26 | alpha-Linolenic Acid | — | 300 |
| 27 | Dactinomycin | — | 297 |
About the Negative regulation of MET activity Pathway
The Negative regulation of MET activity pathway is catalogued in Reactome (ID: R-HSA-6807004) and involves 5 genes. In the BiohacksAI corpus, 27 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include GRB2, MET, PTPN1, PTPN2, USP8.