Pyruvate metabolism
REACTOME PATHWAYThe Pyruvate metabolism pathway (Reactome ID: R-HSA-70268) involves 5 genes and is affected by 20 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Pyruvate metabolism
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | fisetin | — | 78 |
| 2 | myricetin-3-O-galactopyranoside [Supplementary Concept] | — | 300 |
| 3 | Suramin | — | 300 |
| 4 | Apigenin 5,7,4'-trihydroxy-flavone, | — | 300 |
| 5 | alphitonin [Supplementary Concept] from | — | 300 |
| 6 | Sirolimus | — | 300 |
| 7 | Spermidine | — | 241 |
| 8 | Catechin | — | 300 |
| 9 | Niclosamide | — | 299 |
| 10 | pd98059 | — | 7 |
| 11 | Pseudoephedrine | — | 298 |
| 12 | egcg | — | 300 |
| 13 | Rutin | — | 300 |
| 14 | Oxaprozin | — | 181 |
| 15 | Pioglitazone | — | 297 |
| 16 | streptonigrin | — | 299 |
| 17 | piceatannol | — | 300 |
| 18 | Luteolin 5,7,3',4'-tetrahydroxy-flavone, | — | 150 |
| 19 | Quercetin | — | 300 |
| 20 | chrysin | — | 300 |
About the Pyruvate metabolism Pathway
The Pyruvate metabolism pathway is catalogued in Reactome (ID: R-HSA-70268) and involves 5 genes. In the BiohacksAI corpus, 20 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include DLD, GLO1, PDK1, PKLR, PKM.