What genes are in the Processing of Capped Intron-Containing Pre-mRNA pathway?

The Processing of Capped Intron-Containing Pre-mRNA pathway involves 7 genes. Key genes include: HNRNPA1, HSPA8, METTL14, METTL3, PPP1CA, PTBP1, SF3B3.

Processing of Capped Intron-Containing Pre-mRNA

Q: What compounds affect the Processing of Capped Intron-Containing Pre-mRNA pathway?

31 compounds in the BiohacksAI corpus have documented interactions with genes in the Processing of Capped Intron-Containing Pre-mRNA pathway (Reactome ID: R-HSA-72203). These compounds target 7 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-722037 genes31 compounds

The Processing of Capped Intron-Containing Pre-mRNA pathway (Reactome ID: R-HSA-72203) involves 7 genes and is affected by 31 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

HNRNPA1 HSPA8 METTL14 METTL3 PPP1CA PTBP1 SF3B3

Compounds Affecting Processing of Capped Intron-Containing Pre-mRNA

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	Hexachlorophene	—	300
3	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
4	Anthralin	—	299
5	Mometasone Furoate	—	292
6	Oxytetracycline	—	300
7	Thyroxine	—	994
8	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
9	Aurintricarboxylic Acid	—	184
10	Calcimycin	—	216
11	Chlorhexidine	—	299
12	Clotrimazole	—	296
13	Fluspirilene	—	74
14	Tetracycline	—	300
15	Thyroxine	—	300
16	Azauridine	—	300
17	Carboxin	—	174
18	Digitoxin	—	300
19	Digoxin	—	299
20	Ethylenethiourea	—	300
21	Nadolol	—	297
22	Ouabain	—	300
23	streptonigrin	—	299
24	Sulfadiazine	—	298
25	Thioridazine	—	35
26	triflupromazine hydrochloride	—	12
27	s adenosylhomocysteine	—	300
28	Adenosine Diphosphate Adenosine 5'-(trihydrogen diphosphate).	—	300
29	Ergosterol	—	300
30	Camptothecin	—	300
31	trichostatic acid [Supplementary Concept] related to trichostatin	—	300

About the Processing of Capped Intron-Containing Pre-mRNA Pathway

The Processing of Capped Intron-Containing Pre-mRNA pathway is catalogued in Reactome (ID: R-HSA-72203) and involves 7 genes. In the BiohacksAI corpus, 31 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include HNRNPA1, HSPA8, METTL14, METTL3, PPP1CA.