What compounds affect the Translation pathway?

47 compounds in the BiohacksAI corpus have documented interactions with genes in the Translation pathway (Reactome ID: R-HSA-72766). These compounds target 47 genes within this pathway.

What genes are in the Translation pathway?

The Translation pathway involves 47 genes. Key genes include: ADRM1, COX1, COX2, EEF2, EIF4A1, EIF4G1, EIF4H, IARS1, KARS1, LARS1.

Translation

REACTOME PATHWAY

Reactome: R-HSA-7276647 genes47 compounds

The Translation pathway (Reactome ID: R-HSA-72766) involves 47 genes and is affected by 47 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 COX1 COX2 EEF2 EIF4A1 EIF4G1 EIF4H IARS1 KARS1 LARS1 MARS2 ND4 PABPC1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3+17 more

Compounds Affecting Translation

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	egcg	—	300
4	Hexachlorophene	—	300
5	Oxytetracycline	—	300
6	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
7	Oxcarbazepine	—	296
8	Rosmarinic Acid	—	300
9	Rutin	—	300
10	Phenoxybenzamine	—	21
11	cycloheximide	—	300
12	Disulfiram	—	297
13	4-Hydroxybenzoate-3-Monooxygenase	—	300
14	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
15	chrysin	—	300
16	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
17	Quercetin	—	300
18	Genistein	—	300
19	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
20	Anthralin	—	299
21	Cefixime	—	300
22	Ethidium	—	300
23	sp600125	—	117
24	Temozolomide	—	299
25	Metronidazole	—	300
26	Corticosterone	—	300
27	Diphenhydramine	—	14
28	DEAD-box RNA Helicases	—	169
29	Thioctic Acid	—	298
30	Thioctic Acid	—	300
31	Azauridine	—	300
32	Levetiracetam	—	296
33	Clotrimazole	—	296
34	Demeclocycline	—	5
35	Edaravone	—	298
36	Adenosine Diphosphate Adenosine 5'-(trihydrogen diphosphate).	—	300
37	Pioglitazone	—	297
38	Harmaline	—	300
39	Daunorubicin	—	298
40	Rotenone	—	300
41	Doxycycline	—	999
42	Sirolimus	—	300
43	Celecoxib	—	295
44	Chloramphenicol	—	297
45	methyl 13-(alpha-naphthalene)aminodeisopropyldehydroabietate [Supplementary Concept]	—	161
46	Mupirocin	—	299
47	ninhydrin	—	300

About the Translation Pathway

The Translation pathway is catalogued in Reactome (ID: R-HSA-72766) and involves 47 genes. In the BiohacksAI corpus, 47 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, COX1, COX2, EEF2, EIF4A1.