What compounds affect the Resolution of Abasic Sites (AP sites) pathway?

58 compounds in the BiohacksAI corpus have documented interactions with genes in the Resolution of Abasic Sites (AP sites) pathway (Reactome ID: R-HSA-73933). These compounds target 7 genes within this pathway.

What genes are in the Resolution of Abasic Sites (AP sites) pathway?

The Resolution of Abasic Sites (AP sites) pathway involves 7 genes. Key genes include: APEX1, FEN1, MPG, OGG1, PARP1, PCNA, POLB.

Resolution of Abasic Sites (AP sites)

REACTOME PATHWAY

Reactome: R-HSA-739337 genes58 compounds

The Resolution of Abasic Sites (AP sites) pathway (Reactome ID: R-HSA-73933) involves 7 genes and is affected by 58 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

APEX1 FEN1 MPG OGG1 PARP1 PCNA POLB

Compounds Affecting Resolution of Abasic Sites (AP sites)

#	Compound	Targets Hit	Studies
1	Aurintricarboxylic Acid	—	184
2	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
3	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
4	Oleanolic Acid	—	300
5	Methyldopa	—	297
6	Methylene Blue	—	200
7	Quercetin	—	300
8	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
9	Idarubicin	—	299
10	Oxytetracycline	—	300
11	piceatannol	—	300
12	streptonigrin	—	299
13	stigmasterol	—	300
14	4-Hydroxybenzoate-3-Monooxygenase	—	300
15	Ursolic Acid	—	300
16	DEAD-box RNA Helicases	—	169
17	Thioctic Acid	—	298
18	egcg	—	300
19	Rosmarinic Acid	—	300
20	Rutin	—	300
21	Methotrexate	—	289
22	calycosin	—	300
23	Demeclocycline	—	5
24	Dequalinium	—	46
25	Hexachlorophene	—	300
26	Nitroprusside	—	299
27	sp600125	—	117
28	Stavudine	—	298
29	alphitonin [Supplementary Concept] from	—	300
30	Thioctic Acid	—	300
31	Norepinephrine Precursor of epinephrine that is secreted by	—	298
32	Dequalinium	—	136
33	Diiodotyrosine	—	300
34	Epinephrine	—	299
35	Ethidium	—	300
36	Levodopa	—	297
37	Doxycycline	—	999
38	Carmine Coloring matter from	—	300
39	Cisplatin	—	300
40	Demeclocycline	—	297
41	Dithiazanine 3-Ethyl-2-(5-(3-ethyl-2-benzothiazolinylidene)-1,3- pentadienyl)benzothiazolium.	—	135
42	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
43	Bortezomib	—	300
44	Camptothecin	—	300
45	Clofarabine	—	298
46	Daunorubicin	—	298
47	Demecolcine	—	246
48	Epirubicin	—	300
49	Gemcitabine	—	300
50	Homoharringtonine Semisynthetic derivative of harringtonine that acts as	—	300

About the Resolution of Abasic Sites (AP sites) Pathway

The Resolution of Abasic Sites (AP sites) pathway is catalogued in Reactome (ID: R-HSA-73933) and involves 7 genes. In the BiohacksAI corpus, 58 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include APEX1, FEN1, MPG, OGG1, PARP1.