What compounds affect the Signal attenuation pathway?

31 compounds in the BiohacksAI corpus have documented interactions with genes in the Signal attenuation pathway (Reactome ID: R-HSA-74749). These compounds target 5 genes within this pathway.

What genes are in the Signal attenuation pathway?

The Signal attenuation pathway involves 5 genes. Key genes include: GRB2, INS, INSR, MAPK1, MAPK3.

Signal attenuation

REACTOME PATHWAY

Reactome: R-HSA-747495 genes31 compounds

The Signal attenuation pathway (Reactome ID: R-HSA-74749) involves 5 genes and is affected by 31 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

GRB2 INS INSR MAPK1 MAPK3

Compounds Affecting Signal attenuation

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	plumbagin [Supplementary Concept]	—	300
3	pd98059	—	7
4	alsterpaullone	—	12
5	kenpaullone	—	8
6	sp600125	—	117
7	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
8	trametinib	—	296
9	withaferin	—	300
10	tyrphostin ag 1478	—	4
11	Clotrimazole	—	296
12	fisetin	—	78
13	Progesterone	—	299
14	2-Chloroadenosine 2-Chloroadenosine.	—	300
15	Benzalkonium Compounds	—	299
16	Calcimycin	—	216
17	daph	—	2
18	Diphenhydramine	—	14
19	ha1004	—	4
20	Lithocholic Acid	—	300
21	Loratadine	—	296
22	trequinsin hydrochloride	—	1
23	Crizotinib	—	298
24	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
25	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
26	Digitoxin	—	300
27	Digoxin	—	299
28	Flutamide	—	298
29	m084	—	2
30	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
31	Dactinomycin	—	297

About the Signal attenuation Pathway

The Signal attenuation pathway is catalogued in Reactome (ID: R-HSA-74749) and involves 5 genes. In the BiohacksAI corpus, 31 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include GRB2, INS, INSR, MAPK1, MAPK3.