TNF signaling
REACTOME PATHWAYThe TNF signaling pathway (Reactome ID: R-HSA-75893) involves 9 genes and is affected by 17 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting TNF signaling
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Crizotinib | — | 298 |
| 2 | Adenosine Triphosphate | — | 300 |
| 3 | chicoric acid | — | 117 |
| 4 | amlexanox | — | 96 |
| 5 | Sorafenib | — | 300 |
| 6 | Adenosine | — | 298 |
| 7 | Adenosine Diphosphate Adenosine 5'-(trihydrogen diphosphate). | — | 300 |
| 8 | alsterpaullone | — | 12 |
| 9 | Aurintricarboxylic Acid | — | 184 |
| 10 | sp600125 | — | 117 |
| 11 | Bisphenol A-Glycidyl Methacrylate | — | 197 |
| 12 | Kaempferols | — | 300 |
| 13 | Prednisolone | — | 1,000 |
| 14 | Axitinib | — | 298 |
| 15 | Afatinib | — | 297 |
| 16 | glaucarubinone | — | 10 |
| 17 | Gliotoxin | — | 300 |
About the TNF signaling Pathway
The TNF signaling pathway is catalogued in Reactome (ID: R-HSA-75893) and involves 9 genes. In the BiohacksAI corpus, 17 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADAM17, CHUK, IKBKB, IKBKE, MAP3K7.