What genes are in the Organic anion transport by SLCO transporters pathway?

The Organic anion transport by SLCO transporters pathway involves 8 genes. Key genes include: SLCO1A2, SLCO1B1, SLCO1B3, SLCO1C1, SLCO2B1, SLCO3A1, SLCO4A1, SLCO4C1.

Organic anion transport by SLCO transporters

Q: What compounds affect the Organic anion transport by SLCO transporters pathway?

40 compounds in the BiohacksAI corpus have documented interactions with genes in the Organic anion transport by SLCO transporters pathway (Reactome ID: R-HSA-879518). These compounds target 8 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-8795188 genes40 compounds

The Organic anion transport by SLCO transporters pathway (Reactome ID: R-HSA-879518) involves 8 genes and is affected by 40 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

SLCO1A2 SLCO1B1 SLCO1B3 SLCO1C1 SLCO2B1 SLCO3A1 SLCO4A1 SLCO4C1

Compounds Affecting Organic anion transport by SLCO transporters

#	Compound	Targets Hit	Studies
1	Triiodothyronine	—	300
2	Rifamycins	—	300
3	Rifamycins	—	300
4	Thyroxine	—	994
5	Thyroxine	—	300
6	Ritonavir	—	298
7	Atorvastatin	—	1,000
8	Genistein	—	300
9	Silymarin	—	10
10	Bilirubin	—	296
11	Pravastatin	—	297
12	Arachidonic Acid	—	245
13	Losartan	—	1,000
14	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
15	beta Carotene	—	299
16	candesartan cilexetil [Supplementary Concept]	—	300
17	Gemfibrozil	—	297
18	Glyburide	—	298
19	Mometasone Furoate	—	292
20	Olmesartan Medoxomil	—	300
21	Antimycin	—	300
22	Digoxin	—	299
23	Taurocholic Acid	—	300
24	Alprostadil	—	297
25	Simvastatin	—	1,000
26	Sirolimus	—	300
27	Vincristine	—	299
28	Dinoprostone	—	296
29	fisetin	—	78
30	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
31	Quercetin	—	300
32	scutellarein	—	113
33	Dinoprost	—	252
34	Prostaglandin D2	—	300
35	naringin	—	300
36	Dehydroepiandrosterone Sulfate	—	300
37	Digitoxin	—	300
38	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
39	Ouabain	—	300
40	Dextrothyroxine	—	134

About the Organic anion transport by SLCO transporters Pathway

The Organic anion transport by SLCO transporters pathway is catalogued in Reactome (ID: R-HSA-879518) and involves 8 genes. In the BiohacksAI corpus, 40 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include SLCO1A2, SLCO1B1, SLCO1B3, SLCO1C1, SLCO2B1.