What genes are in the Regulation of PTEN stability and activity pathway?

The Regulation of PTEN stability and activity pathway involves 40 genes. Key genes include: ADRM1, AKT3, CSNK2A1, CSNK2A2, CSNK2B, FRK, OTUD3, PSMA1, PSMA2, PSMA3.

Regulation of PTEN stability and activity

Q: What compounds affect the Regulation of PTEN stability and activity pathway?

34 compounds in the BiohacksAI corpus have documented interactions with genes in the Regulation of PTEN stability and activity pathway (Reactome ID: R-HSA-8948751). These compounds target 40 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-894875140 genes34 compounds

The Regulation of PTEN stability and activity pathway (Reactome ID: R-HSA-8948751) involves 40 genes and is affected by 34 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 AKT3 CSNK2A1 CSNK2A2 CSNK2B FRK OTUD3 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12+10 more

Compounds Affecting Regulation of PTEN stability and activity

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
4	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
5	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
6	Quercetin	—	300
7	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
8	chrysin	—	300
9	fisetin	—	78
10	Kaempferols	—	300
11	Vanillic Acid	—	300
12	ly294002	—	11
13	sp600125	—	117
14	Dichlororibofuranosylbenzimidazole	—	26
15	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300
16	alsterpaullone	—	12
17	kenpaullone	—	8
18	pictilisib	—	25
19	Axitinib	—	298
20	Disulfiram	—	297
21	4-Hydroxybenzoate-3-Monooxygenase	—	300
22	egcg	—	300
23	Genistein	—	300
24	alpha-Linolenic Acid	—	300
25	salvin [Supplementary Concept]	—	300
26	carnosol	—	198
27	piceatannol	—	300
28	Sorafenib	—	300
29	Dasatinib	—	299
30	Afatinib	—	297
31	Crizotinib	—	298
32	Pioglitazone	—	297
33	Harmaline	—	300
34	hydroxyfasudil [Supplementary Concept]	—	11

About the Regulation of PTEN stability and activity Pathway

The Regulation of PTEN stability and activity pathway is catalogued in Reactome (ID: R-HSA-8948751) and involves 40 genes. In the BiohacksAI corpus, 34 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, AKT3, CSNK2A1, CSNK2A2, CSNK2B.