What compounds affect the Triglyceride metabolism pathway?

26 compounds in the BiohacksAI corpus have documented interactions with genes in the Triglyceride metabolism pathway (Reactome ID: R-HSA-8979227). These compounds target 11 genes within this pathway.

What genes are in the Triglyceride metabolism pathway?

The Triglyceride metabolism pathway involves 11 genes. Key genes include: FABP2, FABP3, FABP4, FABP5, MGLL, PLIN1, PPP1CA, PPP1CC, PRKACA, PRKACB.

Triglyceride metabolism

REACTOME PATHWAY

Reactome: R-HSA-897922711 genes26 compounds

The Triglyceride metabolism pathway (Reactome ID: R-HSA-8979227) involves 11 genes and is affected by 26 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

FABP2 FABP3 FABP4 FABP5 MGLL PLIN1 PPP1CA PPP1CC PRKACA PRKACB PRKACG

Compounds Affecting Triglyceride metabolism

#	Compound	Targets Hit	Studies
1	Palmitic Acid	—	300
2	Linoleic Acid	—	300
3	hydroxyfasudil [Supplementary Concept]	—	11
4	Chlorhexidine	—	299
5	Arachidonic Acid	—	245
6	Oleic Acid	—	112
7	Anthralin	—	299
8	Hexachlorophene	—	300
9	Mometasone Furoate	—	292
10	Oxytetracycline	—	300
11	Thyroxine	—	994
12	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
13	Aurintricarboxylic Acid	—	184
14	Calcimycin	—	216
15	Clotrimazole	—	296
16	Fluspirilene	—	74
17	Tetracycline	—	300
18	Thyroxine	—	300
19	Mepentol [Supplementary Concept]	—	184
20	Disulfiram	—	297
21	Vitamin K 3	—	300
22	alpelisib	—	227
23	Fenofibrate	—	297
24	Sphingosine	—	300
25	kml29	—	6
26	Okadaic Acid	—	300

About the Triglyceride metabolism Pathway

The Triglyceride metabolism pathway is catalogued in Reactome (ID: R-HSA-8979227) and involves 11 genes. In the BiohacksAI corpus, 26 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include FABP2, FABP3, FABP4, FABP5, MGLL.