What compounds affect the CDC42 GTPase cycle pathway?

26 compounds in the BiohacksAI corpus have documented interactions with genes in the CDC42 GTPase cycle pathway (Reactome ID: R-HSA-9013148). These compounds target 13 genes within this pathway.

What genes are in the CDC42 GTPase cycle pathway?

The CDC42 GTPase cycle pathway involves 13 genes. Key genes include: ARHGAP35, BCR, BUB1B-PAK6, CDC42, CDC42BPA, CDC42BPB, PAK4, PAK5, PAK6, PIK3R1.

CDC42 GTPase cycle

REACTOME PATHWAY

Reactome: R-HSA-901314813 genes26 compounds

The CDC42 GTPase cycle pathway (Reactome ID: R-HSA-9013148) involves 13 genes and is affected by 26 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ARHGAP35 BCR BUB1B-PAK6 CDC42 CDC42BPA CDC42BPB PAK4 PAK5 PAK6 PIK3R1 PIK3R2 RAB7A RACGAP1

Compounds Affecting CDC42 GTPase cycle

#	Compound	Targets Hit	Studies
1	kenpaullone	—	8
2	Axitinib	—	298
3	alsterpaullone	—	12
4	pictilisib	—	25
5	ly294002	—	11
6	Sirolimus	—	300
7	torin 1	—	10
8	Dasatinib	—	299
9	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
10	triolimus [Supplementary Concept]	—	33
11	pterostilbene	—	299
12	Crizotinib	—	298
13	Imatinib Mesylate	—	300
14	Sorafenib	—	300
15	Wortmannin	—	300
16	alpelisib	—	227
17	Quercetin	—	300
18	Pueraria	—	300
19	Kaempferols	—	300
20	Catechin	—	300
21	Equilin	—	216
22	Hydrocortisone	—	299
23	Hydrocortisone	—	298
24	Guanosine Diphosphate	—	300
25	Guanosine Triphosphate Guanosine 5'-(tetrahydrogen triphosphate).	—	300
26	casin	—	10

About the CDC42 GTPase cycle Pathway

The CDC42 GTPase cycle pathway is catalogued in Reactome (ID: R-HSA-9013148) and involves 13 genes. In the BiohacksAI corpus, 26 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ARHGAP35, BCR, BUB1B-PAK6, CDC42, CDC42BPA.